Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

Autor: Eiko K. de Jong, Caroline C W Klaver, Marius Ueffing, Tunde Peto, Cécile Delcourt, Sascha Dammeier, Constantin C. Paun, Imre Lengyel, Rosa L. Schellevis, Carel B. Hoyng, Anneke I. den Hollander, Eveline Kersten
Přispěvatelé: Epidemiology, Ophthalmology, Radboud University Medical Center [Nijmegen], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2018
Předmět:
0301 basic medicine
Pathology
medicine.medical_specialty
Retinal Disorder
genetic structures
Disease
Review
Retinal Neovascularization
Proteomics
Bioinformatics
medicine.disease_cause
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
vitreous
03 medical and health sciences
Macular Degeneration
0302 clinical medicine
medicine
Journal Article
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
age-related macular degeneration
plasma
business.industry
aqueous
biomarkers
Lipid metabolism
Complement System Proteins
Macular degeneration
medicine.disease
Lipid Metabolism
eye diseases
3. Good health
Ophthalmology
Oxidative Stress
030104 developmental biology
030221 ophthalmology & optometry
Biomarker (medicine)
sense organs
business
serum
Oxidative stress
Kidney disease
Zdroj: Survey of Ophthalmology, 63, 9-39
Survey of Ophthalmology
Survey of Ophthalmology, 63(1), 9-39. Elsevier Inc.
Survey of Ophthalmology, Elsevier, 2018, 63 (1), pp.9-39. ⟨10.1016/j.survophthal.2017.05.003⟩
Kersten, E, Paun, C C, Schellevis, R L, Hoyng, C B, Delcourt, C, Lengyel, I, Peto, T, Ueffing, M, Klaver, C C W, Dammeier, S, den Hollander, A I & de Jong, E K 2017, ' Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration ', Survey of ophthalmology, vol. 63 . https://doi.org/10.1016/j.survophthal.2017.05.003
Survey of Ophthalmology, 63, 1, pp. 9-39
ISSN: 0039-6257
DOI: 10.1016/j.survophthal.2017.05.003⟩
Popis: Contains fulltext : 190748.pdf (Publisher’s version ) (Open Access) Biomarkers can help unravel mechanisms of disease and identify new targets for therapy. They can also be useful in clinical practice for monitoring disease progression, evaluation of treatment efficacy, and risk assessment in multifactorial diseases, such as age-related macular degeneration (AMD). AMD is a highly prevalent progressive retinal disorder for which multiple genetic and environmental risk factors have been described, but the exact etiology is not yet fully understood. Many compounds have been evaluated for their association with AMD. We performed an extensive literature review of all compounds measured in serum, plasma, vitreous, aqueous humor, and urine of AMD patients. Over 3600 articles were screened, resulting in more than 100 different compounds analyzed in AMD studies, involved in neovascularization, immunity, lipid metabolism, extracellular matrix, oxidative stress, diet, hormones, and comorbidities (such as kidney disease). For each compound, we provide a short description of its function and discuss the results of the studies in relation to its usefulness as AMD biomarker. In addition, biomarkers identified by hypothesis-free techniques, including metabolomics, proteomics, and epigenomics, are covered. In summary, compounds belonging to the oxidative stress pathway, the complement system, and lipid metabolism are the most promising biomarker candidates for AMD. We hope that this comprehensive survey of the literature on systemic and ocular fluid compounds as potential biomarkers in AMD will provide a stepping stone for future research and possible implementation in clinical practice.
Databáze: OpenAIRE
Externí odkaz: