Detection of pancreatic cancer using antibody microarray-based serum protein profiling
| Autor: | Britta Wahren, Johan Ingvarsson, Carsten Peterson, Morten Krogh, Gunnel Engström, Anders Carlsson, Carl A.K. Borrebaeck, Peter Ellmark, Christer Wingren, Ulrika Harmenberg |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Proteomics Pancreatic disease Antibody microarray Antibodies Neoplasm Protein Array Analysis Biochemistry Pancreatic cancer Biomarkers Tumor medicine Humans Immunoglobulin Fragments Molecular Biology Aged Aged 80 and over biology Cancer Blood Proteins Middle Aged medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Pancreatic Neoplasms Proteome Immunology Cancer research biology.protein Adenocarcinoma Female Antibody |
| Zdroj: | PROTEOMICS. 8:2211-2219 |
| ISSN: | 1615-9853 |
| Popis: | The driving force behind oncoproteomics is to identify protein signatures that are associated with a particular malignancy. Here, we have used a recombinant scFv antibody microarray in an attempt to classify sera derived from pancreatic adenocarcinoma patients versus healthy subjects. Based on analysis of nonfractionated, directly labeled, whole human serum proteomes we have identified a protein signature based on 19 nonredundant analytes, that discriminates between cancer patients and healthy subjects. Furthermore, a potential protein signature, consisting of 21 protein analytes, could be defined that was shown to be associated with cancer patients having a life expectancy of |
| Databáze: | OpenAIRE |
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