Rhesus Diploid Rabies Vaccine (Adsorbed): A New Rabies Vaccine Using FRhL-2 Cells
| Autor: | D. W. Brown, J. R. Mitchell, K. D. Kajiya, G. H. Burgoyne |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Virus Cultivation
Rabies Guinea Pigs Immunization Secondary Antibodies Viral medicine.disease_cause Virus Cell Line Microbiology Rabies vaccine medicine Animals Humans Immunology and Allergy Lung Duck embryo vaccine biology Vaccination Rabies virus Immunization Passive medicine.disease Macaca mulatta Virology Infectious Diseases Immunoglobulin M Rabies Vaccines Immunization Immunoglobulin G biology.protein Antibody medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 152:204-210 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/152.1.204 |
| Popis: | The FRhL-2 cell line, a diploid line derived from the lung of a fetal rhesus monkey, was used to prepare a potent rabies vaccine by adapting the Kissling strain of rabies virus to FRhL-2 cells, growing the virus in quantity, inactivating the virus with beta-propiolactone, and concentrating the virus by adsorption to aluminum phosphate. High levels of antibody to rabies virus, induced by the vaccine in both guinea pigs and humans at 14 days after immunization, were determined to be IgG. Data from postexposure protocols with guinea pigs and simulated postexposure protocols in humans showed protection and antibody response even when rabies immune globulin was administered at the time of vaccination. |
| Databáze: | OpenAIRE |
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