Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man
| Autor: | Seppo Kaukinen, Erkki Seppälä, Asko Riutta, T. Kerttula, Heikki Vapaatalo, István Mucha, J. Alanko |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Thromboxane Dopamine Leukotriene Production Radioimmunoassay Prostacyclin 030204 cardiovascular system & hematology Kidney Norepinephrine Thromboxane A2 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Infusions Intravenous Chromatography High Pressure Liquid 030304 developmental biology Leukotriene E4 0303 health sciences Leukotriene Arachidonic Acid Hematology Epoprostenol 3. Good health Endocrinology chemistry Catecholamine Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Thrombosis Research. 80:169-178 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(95)00163-l |
| Popis: | We infused noradrenaline (0.025 micrograms/kg/min for 60 min, n=7) and dopamine (3.0 micrograms/kg/min for 60 min, n=6) into healthy male volunteers to study the effects of these catecholamines on in vivo thromboxane A2, prostacyclin and leukotriene E4 production measured as urinary excretions of 11-dehydro-thromboxane (TX) B2, 2,3-dinor-6-keto-prostaglandin (PG) F1alpha and leukotriene (LT) E4, respectively. Plasma noradrenaline and dopamine concentrations were 2.9+/-0.3 and 233+/-17 nmol/l at the endo fo the noradrenaline and dopamine infusions, respectively. Noradrenaline decreased thromboxane production and increased leukotriene production almost two fold. It had hardly any effect on prostacyclin production. Dopamine had no significant effects on any of the variables, however, it had a tendency to increase prostacyclin and leukotriene production. The results indicate that noradrenaline is a more important modulator of arachidonic acid metabolism than dopamine in vivo. |
| Databáze: | OpenAIRE |
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