Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease
| Autor: | Klemens Ruprecht, Hervé Perron, Mario Clerici, Alois B. Lang, Roberta Mancuso, Patrice Morand, Hans-Peter Hartung, Pablo Villoslada, Corinne Bernard, Cécile Deluen, Raphaëlle Germi, Sébastien Marcel, Ilias Stefas, Giannina Arru, Paul Van-Der-Valk, Rosella Cavaretta, Alain Créange, Peter Rieckmann, Stefano Sotgiu, Francisco Veas, Jean Pelletier, Raphaël Faucard, Jack Van-Horssen, José Boucraut, Claire Gerdil, Domenico Caputo, Marina Saresella, Laurent Farinelli, Michel Chofflon, Marta Garcia-Montojo, Babs O. Fabriek |
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| Přispěvatelé: | Molecular cell biology and Immunology, Pathology, NCA - Multiple Sclerosis and Other Neuroinflammatory Diseases, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2012 |
| Předmět: |
Male
Multiple Sclerosis MSRV Chronic inflammatory demyelinating polyneuropathy Enzyme-Linked Immunosorbent Assay Biology medicine.disease_cause Real-Time Polymerase Chain Reaction Peripheral blood mononuclear cell Autoimmunity 03 medical and health sciences 0302 clinical medicine Antigen Viral Envelope Proteins endogenous retrovirus medicine Humans TLR4 030304 developmental biology 0303 health sciences Clinically isolated syndrome Multiple sclerosis Endogenous Retroviruses Brain Middle Aged medicine.disease Virology Research Papers 3. Good health syncytin Real-time polymerase chain reaction Neurology HERV-W Immunology Biomarker (medicine) biomarker Female Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis (Houndmills, Basingstoke, England) Perron, H, Germi, R, Bernard, C, Garcia-Montojo, M, Deluen, C, Farinelli, L, Faucard, R, Veas, F, Stefas, I, Fabriek, B O, van Horssen, J, van der Valk, P, Gerdil, C, Mancuso, R, Saresella, M, Clerici, M, Marcel, S, Creange, A, Cavaretta, R, Caputo, D, Arru, G, Morand, P, Lang, A B, Sotgiu, S, Ruprecht, K, Rieckmann, P, Villoslada, P, Chofflon, M, Boucraut, J, Pelletier, J & Hartung, H P 2012, ' Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease ', Multiple Sclerosis, vol. 18, no. 12, pp. 1721-1736 . https://doi.org/10.1177/1352458512441381 Multiple Sclerosis, 18(12), 1721-1736. SAGE Publications Ltd Multiple Sclerosis Journal Multiple Sclerosis Journal, SAGE Publications, 2012, 18 (12), pp.1721-36. ⟨10.1177/1352458512441381⟩ Multiple Sclerosis Journal, 2012, 18 (12), pp.1721-36. ⟨10.1177/1352458512441381⟩ |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458512441381 |
| Popis: | Perron, Herve Germi, Raphaelle Bernard, Corinne Garcia-Montojo, Marta Deluen, Cecile Farinelli, Laurent Faucard, Raphael Veas, Francisco Stefas, Ilias Fabriek, Babs O Van-Horssen, Jack Van-der-Valk, Paul Gerdil, Claire Mancuso, Roberta Saresella, Marina Clerici, Mario Marcel, Sebastien Creange, Alain Cavaretta, Rosella Caputo, Domenico Arru, Giannina Morand, Patrice Lang, Alois B Sotgiu, Stefano Ruprecht, Klemens Rieckmann, Peter Villoslada, Pablo Chofflon, Michel Boucraut, Jose Pelletier, Jean Hartung, Hans-Peter England Multiple sclerosis (Houndmills, Basingstoke, England) Mult Scler. 2012 Dec;18(12):1721-36. doi: 10.1177/1352458512441381. Epub 2012 Mar 28.; BACKGROUND: The envelope protein from multiple sclerosis (MS) associated retroviral element (MSRV), a member of the Human Endogenous Retroviral family 'W' (HERV-W), induces dysimmunity and inflammation. OBJECTIVE: The objective of this study was to confirm and specify the association between HERV-W/MSRV envelope (Env) expression and MS. METHODS: 103 MS, 199 healthy controls (HC) and controls with other neurological diseases (28), chronic infections (30) or autoimmunity (30) were analysed with an immunoassay detecting Env in serum. Env RNA or DNA copy numbers in peripheral blood mononuclear cells (PBMC) were determined by a quantitative polymerase chain reaction (PCR). Env was detected by immunohistology in the brains of patients with MS with three specific monoclonals. RESULTS: Env antigen was detected in a serum of 73% of patients with MS with similar prevalence in all clinical forms, and not in chronic infection, systemic lupus, most other neurological diseases and healthy donors (p |
| Databáze: | OpenAIRE |
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