On-Chip High-Pressure Picoliter Injector for Pressure-Driven Flow through Porous Media
| Autor: | Brian Kirby, David S. Reichmuth, Timothy J. Shepodd |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Photochemistry Hydrostatic pressure Analytical chemistry Polymer Injector Buffers Microfluidic Analytical Techniques Silicon Dioxide Analytical Chemistry law.invention chemistry.chemical_compound Fluorocarbon Polymers Acrylates chemistry law High pressure Hydrostatic Pressure Acetonitrile Porous medium Porosity Chromatography High Pressure Liquid Leakage (electronics) |
| Zdroj: | Analytical Chemistry. 76:5063-5068 |
| ISSN: | 1520-6882 0003-2700 |
| DOI: | 10.1021/ac0493572 |
| Popis: | A high-pressure (> 3 MPa) on-chip injector has been developed for microchip applications including HPLC. The mechanical injector is implemented using in situ photopolymerization of fluorinated acrylates inside wet-etched silica microchips. The injector allows reproducible injections as small as 180 pL with < 250 ms duration. The injector operated robustly over 60 days and over 1000 injections. The injector is unique among polymer-based valves as it functions in aqueous, acetonitrile, and mixed buffers at high pressures without detectable leakage. |
| Databáze: | OpenAIRE |
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