A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid
| Autor: | Chang Ho Cho, June Sik Park, Chul Yun Park, Eui Dal Jung, Eon Ju Jeon, Ga Young Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Calcitonin
Pathology medicine.medical_specialty endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Case Report Neuroendocrine tumors Follicular cell lcsh:Diseases of the endocrine glands. Clinical endocrinology Thyroid carcinoma Endocrinology Medicine Carcinoma medullary lcsh:RC648-665 biology business.industry Thyroid medicine.disease medicine.anatomical_structure Medullary carcinoma Synaptophysin biology.protein Thyroglobulin business |
| Zdroj: | Endocrinology and Metabolism, Vol 30, Iss 2, Pp 221-225 (2015) Endocrinology and Metabolism |
| ISSN: | 2093-5978 |
| Popis: | Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management. |
| Databáze: | OpenAIRE |
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