Scintigraphic evaluation of colon targeting pectin–HPMC tablets in healthy volunteers
| Autor: | Bridget O'Mahony, Howard N.E. Stevens, Clive G. Wilson, Murat Türkoğlu, Timuçin Uğurlu, S.M. Connolly, Lee Ann Hodges |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty food.ingredient Compressive Strength Pectin Colon Administration Oral Pharmaceutical Science Pilot Projects Methylcellulose Pharmacology Permeability Dosage form Colon Ascending Drug Delivery Systems Hypromellose Derivatives food Gamma scintigraphy Healthy volunteers Humans Medicine Ascending colon Gastrointestinal Transit Mesalamine Radionuclide Imaging Nisin Gastric emptying business.industry Transverse colon Ileocaecal junction Middle Aged Surgery Gastric Emptying Pectins Technetium Tc 99m Pentetate business Colon Transverse Tablets |
| Zdroj: | International Journal of Pharmaceutics. 370:144-150 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2008.12.002 |
| Popis: | The in vivo evaluation of colon-targeting tablets was conducted in six healthy male volunteers. A pectin-hydroxypropyl methylcellulose coating was compressed onto core tablets labelled with 4MBq (99m)Tc-DTPA. The tablets released in the colon in all subjects; three in the ascending colon (AC) and three in the transverse colon (TC). Tablets that released in the TC had reached the AC before or just after food (Group A). The other three tablets released immediately upon AC entry at least 1.5h post-meal (Group B). Release onset for Group B was earlier than Group A (343min vs 448min). Group B tablets exhibited a clear residence period at the ileocaecal junction (ICJ) which was not observed in Group A. Prolonged residence at the ICJ is assumed to have increased hydration of the hydrogel layer surrounding the core tablet. Forces applied as the tablets progressed through the ICJ may have disrupted the hydrogel layer sufficiently to initiate radiolabel release. Conversely, Group A tablets moved rapidly through the AC to the TC, possibly minimising contact times with water pockets. Inadequate prior hydration of the hydrogel layer preventing access of pectinolytic enzymes and reduced fluid availability in the TC may have retarded tablet disintegration and radiolabel diffusion. |
| Databáze: | OpenAIRE |
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