Community-acquired respiratory virus lower respiratory tract disease in allogeneic stem cell transplantation recipient: Risk factors and mortality from pulmonary virus-bacterial mixed infections

Autor: Carlos Solano, Marisa Calabuig, José Luis Piñana, David Navarro, Aitana Balaguer-Roselló, Estela Giménez, Guillermo Sanz, María Dolores Gómez, Eva Gonzalez, Juan Carlos Hernández-Boluda, Juan Montoro, Víctor Vinuesa, Paula Moles, Miguel Salavert, Jaime Sanz, Ariadna Pérez, Silvia Madrid
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
medicine.medical_treatment
community acquired respiratory virus
Hematopoietic stem cell transplantation
Bronchoalveolar Lavage
Gastroenterology
0302 clinical medicine
Risk Factors
respiratory virus co‐infections
Lung
Respiratory Tract Infections
medicine.diagnostic_test
Respiratory tract infections
Coinfection
Hematopoietic Stem Cell Transplantation
Middle Aged
Community-Acquired Infections
Infectious Diseases
medicine.anatomical_structure
Viruses
virus-bacterial mixed infections
Respiratory virus
Female
Original Article
respiratory virus co-infections
Bronchoalveolar Lavage Fluid
Adult
medicine.medical_specialty
virus‐bacterial mixed infections
030106 microbiology
Context (language use)
CMV DNAemia
Antiviral Agents
03 medical and health sciences
Internal medicine
medicine
Humans
Transplantation
Homologous
allogeneic hematopoietic stem cell transplantation
Aged
Retrospective Studies
Transplantation
Bacteria
business.industry
Fungi
Bacterial pneumonia
Original Articles
medicine.disease
Bronchoalveolar lavage
business
immunodeficiency score index
030215 immunology
Zdroj: TRANSPLANT INFECTIOUS DISEASE
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Transplant Infectious Disease
ISSN: 1398-2273
Popis: Risk factors (RFs) and mortality data of community‐acquired respiratory virus (CARVs) lower respiratory tract disease (LRTD) with concurrent pulmonary co‐infections in the setting of allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is scarce. From January 2011 to December 2017, we retrospectively compared the outcome of allo‐HSCT recipients diagnosed of CARVs LRTD mono‐infection (n = 52, group 1), to those with viral, bacterial, or fungal pulmonary CARVs LRTD co‐infections (n = 15, group 2; n = 20, group 3, and n = 11, group 4, respectively), and with those having bacterial pneumonia mono‐infection (n = 19, group 5). Overall survival (OS) at day 60 after bronchoalveolar lavage (BAL) was significantly higher in group 1, 2, and 4 compared to group 3 (77%, 67%, and 73% vs 35%, respectively, P = .012). Recipients of group 5 showed a trend to better OS compared to those of group 3 (62% vs 35%, P = .1). Multivariate analyses showed bacterial co‐infection as a RF for mortality (hazard ratio[HR] 2.65, 95% C.I. 1.2‐6.9, P = .017). We identified other 3 RFs for mortality: lymphocyte count
Databáze: OpenAIRE
Externí odkaz: