The relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass
| Autor: | M. Onoe, A Lloyd-Thomas, P. Fallon, Martin J. Elliott, Fenella J. Kirkham, Gabriel Chow, Idris Roberts, A D Edwards |
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| Rok vydání: | 1997 |
| Předmět: |
Heart Defects
Congenital Male Pulmonary and Respiratory Medicine Hemodynamics Brain Ischemia law.invention Brain ischemia Risk Factors law Cardiopulmonary bypass medicine Humans Cerebral perfusion pressure Child Hypoxia Brain Intraoperative Complications Cardiopulmonary Bypass business.industry Brain Infant General Medicine Hypoxia (medical) medicine.disease Oxygen surgical procedures operative Cerebral blood flow Regional Blood Flow Vasoconstriction Child Preschool Anesthesia Circulatory system Female Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | European Journal of Cardio-Thoracic Surgery. 11:633-639 |
| ISSN: | 1010-7940 |
| Popis: | Neurological impairment occurs in up to 25% of infants undergoing cardiopulmonary bypass with or without circulatory arrest. Potential causes include alterations in cerebral blood flow, hypoxia and embolisation. During cardiopulmonary bypass, arterial oxygen tension is maintained at levels which under normal conditions cause cerebral vasoconstriction; this is a potential mechanism for ischaemia. The aim of this study was to explore the relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass.Near infrared spectroscopy was used to explore the relation between arterial oxygen tension and cerebral blood flow in 14 patients (median age 8 months; range 1 month to 10 years 11 months). The relations between arterial oxygen tension, arterial carbon dioxide tension, temperature, haematocrit, pump flow rate, mean arterial pressure and cerebral blood flow, were examined using multivariate analysis.There was no relation between cerebral blood flow and arterial oxygen tension, but a highly significant relation was observed between cerebral blood flow and pump flow rate, with cerebral blood flow decreasing 4.2-fold per L.m-2.min-1 decrease of pump flow rate.There was no relation between arterial oxygen tension and cerebral blood flow during cardiopulmonary bypass, but low pump flow rate may lead to reduced cerebral blood flow. |
| Databáze: | OpenAIRE |
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