Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein
| Autor: | Tai-Wing Wu, Kwok-Pui Fung, Chih-Chin Yang, James Lo, Jun Wu, Richard D. Weisel |
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| Rok vydání: | 1995 |
| Předmět: |
Electrophoresis
Lipid Peroxides Radical medicine.medical_treatment Flavonoid Amidines Antioxidants General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Malondialdehyde medicine Humans Organic chemistry General Pharmacology Toxicology and Pharmaceutics Flavonoids chemistry.chemical_classification Lipid peroxide Vitamin E Free Radical Scavengers General Medicine Peroxides Lipoproteins LDL Morin hydrate chemistry Low-density lipoprotein lipids (amino acids peptides and proteins) Trolox Oxidation-Reduction Nuclear chemistry |
| Zdroj: | Life Sciences. 58:PL17-PL22 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(95)02270-8 |
| Popis: | We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of oxidized LDL. On the other hand, Trolox (an analogue of vitamin E) showed less protective effect in the present system. Since free radical mediated oxidation of LDL is implicated to be a cause of atherogenesis, morin hydrate may be a candidate chemotherapeutic agent herein. |
| Databáze: | OpenAIRE |
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