Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children

Autor: Concepcion Saez-Torres, Juan Buades, Nuria Rodriguez, Guiem Frontera, Paula Casasayas, Felix Grases, Antonia Costa-Bauzá, Concepcion Mir, Adrian Rodriguez, Dolores Rodrigo, Cristina Gómez
Rok vydání: 2018
Předmět:
Calcium Phosphates
oxalato de calcio
ácido cítrico
Time Factors
Ca
humanos
030232 urology & nephrology
Calcium oxalate
Ca/Cit ratio
Urine
lcsh:RC870-923
chemistry.chemical_compound
0302 clinical medicine
Crystallization risk
Risk Factors
calcio
obtención de muestra urinaria
Renal Lithiasis
Child
Morning
AP(CaOx) index
Healthy subjects
Cit ratio
General Medicine
adulto
030220 oncology & carcinogenesis
Urinary Calculi
análisis de orina
Crystallization
Research Article
Adult
medicine.medical_specialty
12-h night urine
AP(CaP) index
Urology
Sample (material)
Urinary system
chemistry.chemical_element
Urinalysis
Calcium
Citric Acid
03 medical and health sciences
factores de tiempo
cristalización
cálculos urinarios
medicine
Humans
factores de riesgo
In patient
Urine Specimen Collection
Calcium Oxalate
business.industry
lcsh:Diseases of the genitourinary system. Urology
Reproductive Medicine
chemistry
fosfatos de calcio
business
Zdroj: BMC Urology
BMC Urology, Vol 18, Iss 1, Pp 1-7 (2018)
ISSN: 1471-2490
DOI: 10.1186/s12894-018-0430-8
Popis: BackgroundThe diagnosis and follow-up of stone forming patients is usually performed by analysis of 24-h urine samples. However, crystallization risk varies throughout the day, being higher at night. The main objective of this study is to evaluate the urinary crystallization risk in adults and children by calculating risk indexes based on different collection periods.MethodsThe study included 149 adults (82 healthy and 67 stone-formers) and 108 children (87 healthy and 21 stone-formers). 24-h urine was collected, divided into 12-hdaytime sample (8am to 8pm), and 12-h overnight sample (8pm to 8am next morning). Solute concentrations, the calcium to citrate ratio (Ca/Cit), and the ion activity product of calcium oxalate (AP[CaOx]) and calcium phosphate (AP[CaP]) were calculated in each 12-h sample and in overall 24-h urine. Assessments were also related to stone type.ResultsCa/Cit and AP(CaOx) were significantly higher in stone forming patients than in healthy subjects. The 12-h overnight samples had the highest values for both risk indexes, confirming a greater risk for crystallization at night. The AP(CaP) index was significantly higher in patients with pure hydroxyapatite stones than healthy controls, but was not significantly different between stone-formers overall and healthy controls.ConclusionsThe calculation of risk indexes is a simple method that clinicians can use to estimate crystallization risk. For this purpose, the use of 12-h overnight urine may be a reliable alternative to 24-h collections.
This work was supported by project grant AAEE42/2015 from Conselleria d'Innovacio, Recerca i Turisme, Govern de les Illes Balears. The funders play no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Databáze: OpenAIRE
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