Validity and reliability of the nonalcoholic fatty liver diseases activity score (NAS) in Korean NAFLD patients and its correlation with clinical factors
| Autor: | Yu Jin Kim, Cheol Hee Park, Kyung Rim Huh, Taeho Hahn, Sun-Young Jun, Myung Seok Lee, Kwang Seon Min, Kyo Sang Yoo, Choong Kee Park, Kyung Hun Lee, Kyoung Oh Kim, Sang Hoon Park, Jong Hyeok Kim |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Validation Studies as Topic Severity of Illness Index Gastroenterology Insulin resistance Asian People Internal medicine Republic of Korea Severity of illness medicine Humans Triglycerides Retrospective Studies Ultrasonography medicine.diagnostic_test biology business.industry Fatty liver Reproducibility of Results Alanine Transaminase General Medicine Middle Aged medicine.disease Fibrosis digestive system diseases Fatty Liver Alanine transaminase Liver biopsy Ferritins biology.protein Female Insulin Resistance Steatosis Lipid profile business Body mass index |
| Zdroj: | The Korean Journal of Hepatology. 16:29 |
| ISSN: | 1738-222X |
| Popis: | Background/Aim: Nonalcoholic steatohepatitis (NASH) is commonly diagnosed using the semi-quantitative grading and staging system proposed by Brunt et al. in 1999. The Pathology Committee of the NASH established the nonalcoholic fatty liver diseases (NAFLD) activity score (NAS) in 2005. The aim of this study was to elucidate the validity and reliability of the NAS in Korean NAFLD patients. Methods: Fifty-six patients on whom sonography-guided liver biopsy for well-defined NAFLD was performed between 1999 and 2007 were identified retrospectively. Two pathologists evaluated each biopsy sample. NAFLD was evaluated using both the grading system developed by Brunt et al. and the NAS. Each pathologist was blinded to the patients’ clinical data and scored independently. We evaluated the body mass index (BMI), liver enzymes, lipid profile, peripheral insulin resistance, leptin, insulin/c-peptide ratio, ferritin, and fasting blood glucose. Results: The patients were aged 32.1±12.5 years (mean±SD) and comprised 44 males (78.6%). Patients with different grades at the two grading systems had mild steatosis or ballooning changes with fibrosis, and 36.6% of them were borderline cases (NAS of 3 or 4). The interobserver agreement on diagnostic category was 0.748 (P |
| Databáze: | OpenAIRE |
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