Regulation of Gene Expression by HTLV-I Tax Protein
| Autor: | Richard B. Gaynor, F Bex |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Gene Expression Regulation
Viral Transcriptional Activation Therapeutic gene modulation viruses CREB General Biochemistry Genetics and Molecular Biology Nuclear Receptor Coactivator 3 Viral Proteins Gene expression Humans Cyclic AMP Response Element-Binding Protein Promoter Regions Genetic Molecular Biology Histone Acetyltransferases Regulator gene Genetics Regulation of gene expression ABL biology NF-kappa B RUNX1T1 Gene Products tax Enhancer Elements Genetic HIV-1 Trans-Activators biology.protein |
| Zdroj: | Methods. 16:83-94 |
| ISSN: | 1046-2023 |
| DOI: | 10.1006/meth.1998.0646 |
| Popis: | The human T-cell leukemia virus type I or HTLV-I is the causative agent of adult T-cell leukemia. A protein encoded by HTLV-I, Tax, activates viral gene expression and is essential for transforming T-lymphocytes. Tax activates HTLV-I gene expression via interactions with the ATF/CREB proteins and the coactivators CBP/p300 which assemble as a multiprotein complex on regulatory elements known as 21-bp repeats in the HTLV-I LTR. Tax can also activate expression from cellular genes including the interleukin-2 (IL-2) and the IL-2 receptor genes via increases in nuclear levels of NF-kappaB. Tax modulation of gene expression via the ATF/CREB and NF-kappaB pathways is linked to its transforming properties. This review discusses the mechanisms by which Tax regulates viral and cellular gene expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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