Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial
| Autor: | Ross N. Butler, Geoffrey P. Davidson, Taher Omari, Marc A. Benninga, Lloyd Sansom, John Dent |
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| Přispěvatelé: | Omari, T, Benninga, M, Sansom, L, Butler, Ross Norman, Dent, John, Davidson, Geoffrey, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Gastroenterology |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Baclofen Adolescent medicine.drug_class Clinical Sciences Placebo Paediatrics and Reproductive Medicine chemistry.chemical_compound Double-Blind Method Humans Medicine Child GABA Agonists Breath test medicine.diagnostic_test Gastric emptying business.industry Esophageal disease Reflux Muscle relaxant medicine.disease chemistry Child Preschool Anesthesia Pediatrics Perinatology and Child Health Gastroesophageal Reflux GERD Female Gastrointestinal Motility business |
| Zdroj: | Journal of pediatrics, 149(4), 468-474. Mosby Inc. |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2006.05.029 |
| Popis: | OBJECTIVE: To evaluate the effect of baclofen, a gamma-amino-butyric-acid B receptor agonist that inhibits transient lower esophageal sphincter relaxation (TLESR), on the rates of TLESR, gastroesophageal reflux (GER), and gastric emptying (GE) in children with GER disease. STUDY DESIGN: The efficacy of 0.5 mg/kg baclofen was evaluated in a randomized, double-blinded, placebo-controlled trial in 30 children. Patients were intubated with a manometric/pH assembly and given 250 mL of cow's milk. Esophageal motility and pH were then measured for 2 hours (control period). Baclofen or placebo was then administered, and 1 hour later 250 mL of milk was given again and measurements performed for another 2 hours (test period). The GE rate was measured by the (13)C octanoate breath test. RESULTS: Baclofen significantly reduced the incidence of TLESR (mean, 7.3 +/- 1.5 vs 3.6 +/- 1.2 TLESR/2 hours; P < .05) and acid GER (mean 4.2 +/- 0.7 vs 1.7 +/- 1.0 TLESR + GER/2 hours; P < .05) during the test period compared with the control period. Baclofen significantly accelerated the GE rate (median [interquartile range], GE(t1/2), 61 minutes [39, 81 minutes] vs 114 minutes [67, 170 minutes]; P < .05). Baclofen had no effect on the swallowing rate, pattern of esophageal peristalsis, or lower esophageal sphincter pressure. CONCLUSIONS: Baclofen reduces GER in children by inhibiting the triggering of TLESR. Baclofen also accelerates GE |
| Databáze: | OpenAIRE |
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