Gut microbiome-mediated changes in bone metabolism upon infrared light exposure in rats
| Autor: | Hong Liu, Lu Yueying, Jianlou Yang, Chen Dong, Yuming Fu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Bone density
Infrared Rays Ovariectomy 030303 biophysics Osteoporosis Biophysics Physiology 02 engineering and technology Biology Gut flora Bone health Bone and Bones Bone remodeling Rats Sprague-Dawley 03 medical and health sciences Calcitriol Bone Density RNA Ribosomal 16S medicine Animals Radiology Nuclear Medicine and imaging Sunlight 0303 health sciences Principal Component Analysis Radiation Radiological and Ultrasound Technology Bacteria 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Gut microbiome Gastrointestinal Microbiome Rats Ovariectomized rat Female 0210 nano-technology |
| Zdroj: | Journal of photochemistry and photobiology. B, Biology. 217 |
| ISSN: | 1873-2682 |
| Popis: | Adequate sunlight exposure helps reduce bone loss and is important to bone health. Currently, about 90% of the world population spends a major portion of daily life under artificial lighting. Unlike sunlight, LED white light, the main source of artificial lighting, has no infrared radiation, which is known to be beneficial to human health. In artificial lighting environments, infrared supplementation may be used to simulate the effects of sunlight on bone metabolism. Here, we supplemented white LED exposure with infrared light in normal and ovariectomized rats for three consecutive months and examined bone turnover, bone mass, and bone density. We also analyzed the structure and function of gut microbiota in the rats. Infrared supplementation significantly reduced the abundance of Saccharibacteria and increased the abundance of Clostridiaceae 1 and Erysipelotrichaceae bacteria. Our results indicate that changes in the gut microbiome correlate well with bone mass and bone metabolism. Our work demonstrates that infrared supplementation can have a positive effect on rat bone metabolism by affecting gut microbiota. Our findings will be important considerations in the future design of healthy lighting environments that prevent or possibly ameliorate osteoporosis. |
| Databáze: | OpenAIRE |
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