Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults
| Autor: | Andres Cardenas, Simone Ecker, Raj P. Fadadu, Karen Huen, Allan Orozco, Lisa M. McEwen, Hannah-Ruth Engelbrecht, Nicole Gladish, Michael S. Kobor, Luis Rosero-Bixby, William H. Dow, David H. Rehkopf |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Costa Rica Aging Acceleration Cigarette Smoking Epigenesis Genetic Epigenome Genetic Clinical Research Tobacco Genetics Humans Cancer Aged Multidisciplinary Tobacco Smoke and Health MORTALITY Smoking Human Genome Epigenetic DNA Hispanic or Latino DNA Methylation Good Health and Well Being Metilación de ADN Epigenesis |
| Zdroj: | Scientific reports, vol 12, iss 1 Scientific Reports, Vol. 12 Núm. 1: 2022 Kérwá Universidad de Costa Rica instacron:UCR |
| ISSN: | 2045-2322 |
| Popis: | Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DNAm signatures in the Costa Rican Study on Longevity and Healthy Aging (CRELES), including participants from the high longevity region of Nicoya. We measured genome-wide DNAm in leukocytes, tested Epigenetic Age Acceleration (EAA) from five clocks and estimates of telomere length (DNAmTL), and examined effect modification by the high longevity region. 489 participants had a mean (SD) age of 79.4 (10.8) years, and 18% were from Nicoya. Overall, 7.6% reported currently smoking, 35% were former smokers, and 57.4% never smoked. 46 CpGs and five regions (e.g. AHRR, SCARNA6/SNORD39, SNORA20, and F2RL3) were differentially methylated for current smokers. Former smokers had increased Horvath’s EAA (1.69-years; 95% CI 0.72, 2.67), Hannum’s EAA (0.77-years; 95% CI 0.01, 1.52), GrimAge (2.34-years; 95% CI1.66, 3.02), extrinsic EAA (1.27-years; 95% CI 0.34, 2.21), intrinsic EAA (1.03-years; 95% CI 0.12, 1.94) and shorter DNAmTL (− 0.04-kb; 95% CI − 0.08, − 0.01) relative to non-smokers. There was no evidence of effect modification among residents of Nicoya. Our findings recapitulate previously reported and novel smoking-associated DNAm changes in a Latino cohort. UC Berkeley Center on the Economics and Demography of Aging/[]//Estados Unidos United States National Institutes of Health/[]//Estados Unidos UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Tecnologías en Salud UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro Centroamericano de Población (CCP) |
| Databáze: | OpenAIRE |
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