Protein-lipid nanohybrids as emerging platforms for drug and gene delivery: Challenges and outcomes
| Autor: | Waseem Medhat, Ahmed O. Elzoghby, Mark Hany, Mohamed Gaber, Nourhan Saher, Jia-You Fang |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Surface Properties Chemistry Pharmaceutical media_common.quotation_subject Pharmaceutical Science Nanotechnology 02 engineering and technology Gene delivery 030226 pharmacology & pharmacy 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Dendrimer Solid lipid nanoparticle Animals Humans Particle Size Lipid bilayer media_common Liposome Chemistry Gene Transfer Techniques Proteins 021001 nanoscience & nanotechnology Lipids Nanostructures Drug Liberation Drug delivery Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of Controlled Release. 254:75-91 |
| ISSN: | 0168-3659 |
| DOI: | 10.1016/j.jconrel.2017.03.392 |
| Popis: | Nanoparticulate drug delivery systems have been long used to deliver a vast range of drugs and bioactives owing to their ability to demonstrate novel physical, chemical, and/or biological properties. An exponential growth has spurred in research and development of these nanocarriers which led to the evolution of a great number of diverse nanosystems including liposomes, nanoemulsions, solid lipid nanoparticles (SLNs), micelles, dendrimers, polymeric nanoparticles (NPs), metallic NPs, and carbon nanotubes. Among them, lipid-based nanocarriers have made the largest progress whether commercially or under development. Despite this progress, these lipid-based nanocarriers suffer from several limitations that led to the development of many protein-coated lipid nanocarriers. To less extent, protein-based nanocarriers suffer from limitations that led to the fabrication of some lipid bilayer enveloping protein nanocarriers. This review discusses in-depth some limitations associated with the lipid-based or protein-based nanocarriers and the fruitful outcomes brought by protein-lipid hybridization. Also discussed are the various hybridization techniques utilized to formulate these protein-lipid nanohybrids and the mechanisms involved in the drug loading process. |
| Databáze: | OpenAIRE |
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