Ankle-brachial index and peripheral artery disease are not related to restless legs syndrome
Autor: | Hans-Werner Hense, Henry Völzke, Marcus Dörr, Wolfgang Hoffmann, Andras Szentkiralyi, Klaus Berger |
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Rok vydání: | 2017 |
Předmět: |
Male
Comorbidity 030204 cardiovascular system & hematology Severity of Illness Index Body Mass Index 0302 clinical medicine Blood serum Risk Factors Germany Odds Ratio Medicine Prospective Studies Prospective cohort study education.field_of_study Confounding General Medicine Middle Aged diagnostic imaging [Restless Legs Syndrome] diagnostic imaging [Peripheral Arterial Disease] Cardiology Female medicine.medical_specialty Population Peripheral Arterial Disease 03 medical and health sciences Restless Legs Syndrome Internal medicine mental disorders Humans Ankle Brachial Index ddc:610 Risk factor education business.industry physiopathology [Restless Legs Syndrome] Ultrasonography Doppler Odds ratio Confidence interval body regions Cross-Sectional Studies Logistic Models Regional Blood Flow Multivariate Analysis Physical therapy business physiopathology [Peripheral Arterial Disease] Body mass index 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Sleep medicine 35, 74-79 (2017). doi:10.1016/j.sleep.2017.04.010 |
ISSN: | 1389-9457 |
Popis: | Objective Our aim was to investigate the relationship between impaired peripheral arterial circulation as measured by ankle-brachial index (ABI) and restless legs syndrome (RLS) in the general population. Methods Data are derived from three independent, German population-based, prospective studies: the control sample of BiDirect ( N = 966), the second follow-up of SHIP ( N = 2333), and a subsample of SHIP-Trend ( N = 1269). RLS was assessed with questions based on the RLS minimal criteria. ABI was measured with an automated method in BiDirect and with Doppler ultrasound in both SHIP studies. An ABI score below 0.9 was indicative of peripheral arterial disease (PAD). Co-morbidities, medications and behavioural factors were self-reported. Additional measurements included body mass index and haemoglobin from blood serum. For BiDirect, a follow-up with identical methodology was performed after a median of 2.5 years. Results In cross-sectional analyses, decreased ABI was not significantly associated with RLS as outcome in multivariable logistic regression models adjusted for several potential confounders (BiDirect: odds ratio (OR) = 1.07 for a −0.1 change in ABI, 95% confidence interval (CI): 0.81–1.42, p = 0.62; SHIP-2: OR = 0.99, CI: 0.85–1.16, p = 0.94; SHIP-Trend: OR = 0.99, CI: 0.87–1.13, p = 0.88). Similar non-significant results were achieved using PAD (instead of ABI) as an independent variable. In BiDirect, baseline ABI was not a significant predictor of incident RLS in longitudinal analysis (OR = 0.77, CI: 0.53–1.12, p = 0.17). Conclusion Results from three independent studies suggest that reduced ABI is not a risk factor for RLS in the general population. |
Databáze: | OpenAIRE |
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