Ankle-brachial index and peripheral artery disease are not related to restless legs syndrome

Autor: Hans-Werner Hense, Henry Völzke, Marcus Dörr, Wolfgang Hoffmann, Andras Szentkiralyi, Klaus Berger
Rok vydání: 2017
Předmět:
Male
Comorbidity
030204 cardiovascular system & hematology
Severity of Illness Index
Body Mass Index
0302 clinical medicine
Blood serum
Risk Factors
Germany
Odds Ratio
Medicine
Prospective Studies
Prospective cohort study
education.field_of_study
Confounding
General Medicine
Middle Aged
diagnostic imaging [Restless Legs Syndrome]
diagnostic imaging [Peripheral Arterial Disease]
Cardiology
Female
medicine.medical_specialty
Population
Peripheral Arterial Disease
03 medical and health sciences
Restless Legs Syndrome
Internal medicine
mental disorders
Humans
Ankle Brachial Index
ddc:610
Risk factor
education
business.industry
physiopathology [Restless Legs Syndrome]
Ultrasonography
Doppler
Odds ratio
Confidence interval
body regions
Cross-Sectional Studies
Logistic Models
Regional Blood Flow
Multivariate Analysis
Physical therapy
business
physiopathology [Peripheral Arterial Disease]
Body mass index
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Sleep medicine 35, 74-79 (2017). doi:10.1016/j.sleep.2017.04.010
ISSN: 1389-9457
Popis: Objective Our aim was to investigate the relationship between impaired peripheral arterial circulation as measured by ankle-brachial index (ABI) and restless legs syndrome (RLS) in the general population. Methods Data are derived from three independent, German population-based, prospective studies: the control sample of BiDirect ( N = 966), the second follow-up of SHIP ( N = 2333), and a subsample of SHIP-Trend ( N = 1269). RLS was assessed with questions based on the RLS minimal criteria. ABI was measured with an automated method in BiDirect and with Doppler ultrasound in both SHIP studies. An ABI score below 0.9 was indicative of peripheral arterial disease (PAD). Co-morbidities, medications and behavioural factors were self-reported. Additional measurements included body mass index and haemoglobin from blood serum. For BiDirect, a follow-up with identical methodology was performed after a median of 2.5 years. Results In cross-sectional analyses, decreased ABI was not significantly associated with RLS as outcome in multivariable logistic regression models adjusted for several potential confounders (BiDirect: odds ratio (OR) = 1.07 for a −0.1 change in ABI, 95% confidence interval (CI): 0.81–1.42, p = 0.62; SHIP-2: OR = 0.99, CI: 0.85–1.16, p = 0.94; SHIP-Trend: OR = 0.99, CI: 0.87–1.13, p = 0.88). Similar non-significant results were achieved using PAD (instead of ABI) as an independent variable. In BiDirect, baseline ABI was not a significant predictor of incident RLS in longitudinal analysis (OR = 0.77, CI: 0.53–1.12, p = 0.17). Conclusion Results from three independent studies suggest that reduced ABI is not a risk factor for RLS in the general population.
Databáze: OpenAIRE
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