| Autor: |
Steffi Oesterreich, Azadeh Nasrazadani, Jian Zou, Neil Carleton, Tiffany Onger, Matthew D Wright, Yujia Li, Kathryn Demanelis, Bhuvaneswari Ramaswamy, George Tseng, Adrian V Lee, Nicole Williams, Megan Kruse |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the National Cancer Institute. 114(11) |
| ISSN: |
1460-2105 |
| Popis: |
Background There is increasing interest in better understanding the biology and clinical presentation of invasive lobular cancer (ILC), which is the most common special histological subtype of breast cancer. Limited large contemporary data sets are available allowing comparison of clinicopathologic features between ILC and invasive ductal cancer (IDC). Methods The Great Lakes Breast Cancer Consortium was formed to compare clinical behavior of ILC (n = 3617) and IDC (n = 30 045) from 33 662 patients treated between 1990 and 2017 at 3 large clinical centers. We used Kaplan-Meier analysis, Cox proportional hazards modeling, and propensity score matching to evaluate treatment differences and outcomes. All statistical testing used 2-sided P values. Results Compared with IDC, patients with ILC were more frequently diagnosed at later stages and with more lymph node involvement (corrected P Conclusions This large, retrospective, collaborative analysis with 3 clinical centers identified meaningful differences in clinicopathological features between ILC and IDC, providing further evidence that these are 2 different entities requiring different clinical management. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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