Functional state of corticostriatal synapses determines their expression of short- and long-term plasticity
| Autor: | Wael Musleh, John P. Walsh, Rebecca Smith, Garnik Akopian |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Nifedipine Population Action Potentials Plasticity Biology Cellular and Molecular Neuroscience Postsynaptic potential Neuroplasticity medicine Animals education Cerebral Cortex education.field_of_study Neuronal Plasticity Excitatory Postsynaptic Potentials Long-term potentiation Calcium Channel Blockers Corpus Striatum Rats medicine.anatomical_structure Cerebral cortex Synaptic plasticity Synapses Excitatory postsynaptic potential Neuroscience |
| Zdroj: | Synapse (New York, N.Y.). 38(3) |
| ISSN: | 0887-4476 |
| Popis: | Relationships between presynaptic function and short- and long-term plasticity were investigated at adult corticostriatal synapses. Wide variability was observed in the expression of short- and long-term synaptic plasticity. Intracellular records from 47 cells produced 17 examples of LTD (90% of control), 10 examples of no long-term change (between 90-110% of control), and 20 examples of LTP (110% of control). Similar variation existed in paired-pulse and posttetanic plasticities. The variability expressed in all three forms of plasticity appears to be related, based on correlations found between the paired-pulse ratio (PPR) and tetanus-induced short- (3 min posttetanus) and long-term plasticities (16-20 min posttetanus). These data suggest that tetanus-induced changes in synaptic strength are related to the intrinsic, preconditioned behavior of synapses. Every cell showing paired-pulse depression also expressed LTD in response to high-frequency activation of its afferents. Those synapses showing paired-pulse potentiation tended to express LTP, although exceptions did exist. Similar relationships were found in a parallel analysis of population spikes. PPR also changed in association with the expression of posttetanic and long-term depression. Greater paired-pulse potentiation was observed in medial intracellular recordings, but no medial to lateral differences were seen in posttetanic plasticities. Field recordings also showed a medial bias toward paired-pulse and posttetanic potentiation, but not in long-term plasticity. Block of postsynaptic L-type Ca(2+) channels with nifedipine eliminated LTD expression, but overall no differences were found between nifedipine and control cells. |
| Databáze: | OpenAIRE |
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