Evaluation of the World Health Organization staging system for HIV infection and disease in Ethiopia: association between clinical stages and laboratory markers
| Autor: | S Jurriaans, T F Rinke de Wit, H. Yeneneh, R. A. Coutinho, A L Fontanet, Ermias Hailu, Mulu Girma, H G Mariam, E. Kassa, S Yohannes, Tsehaynesh Messele |
|---|---|
| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Cross-sectional study Immunology HIV Infections Disease World Health Organization Severity of Illness Index Cohort Studies Acquired immunodeficiency syndrome (AIDS) Predictive Value of Tests Internal medicine Severity of illness medicine Humans Immunology and Allergy business.industry Viral Load medicine.disease CD4 Lymphocyte Count Cross-Sectional Studies Infectious Diseases Evaluation Studies as Topic Predictive value of tests Chemoprophylaxis HIV-1 Ethiopia business Viral load Biomarkers Cohort study |
| Zdroj: | AIDS (London, England), 13(3), 381-389. Lippincott Williams and Wilkins |
| ISSN: | 0269-9370 |
| Popis: | OBJECTIVE: To study the association between the clinical axis of the World Health Organization (WHO) staging system of HIV infection and disease and laboratory markers in HIV-infected Ethiopians. DESIGN: Cross-sectional study. METHODS: Clinical manifestations and stage of HIV-positive individuals participating in a cohort study of HIV infection progression, and of HIV-positive patients hospitalized with suspicion of AIDS, were compared to CD4+ T-cell count and viral load. RESULTS: Of the 86 HIV-positive participants of the cohort study, 53 (62%), 16 (19%), 16 (19%), and one (1.2%) were in stage 1, 2, 3 and 4, respectively. Minor weight loss (n = 15) and pulmonary tuberculosis (n = 9) were the most commonly diagnosed conditions among the 38 (44%) symptomatic HIV-positive individuals. Although 23 (27%) HIV-positive participants had CD4+ T-cell counts less than 200 x 10(6)/l, only one was in clinical stage 4. Among 79 hospitalized HIV-positive patients, 15 (19%) and 64 (81%) were in stage 3 and 4, respectively. The majority (83.5%) had CD4+ T-cell counts < 200 x 10(6)/l. Individuals at stage 3 had lower CD4+ T-cell counts and higher viral loads when seen in hospital as compared to cohort participants (P = 0.06 and 0.008, respectively). When grouping the two study populations, the median CD4+ T-cell count decreased (337, 262, 225, 126, and 78 x 10(6)/l, P |
| Databáze: | OpenAIRE |
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