Familial aggregation of major depressive disorder in an African-American community
Autor: | Janet T. Matsunaga, James E. Gangwisch, Eleanor Murphy, Ruth Ottman |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Poison control Psychological Trauma Article 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine mental disorders Odds Ratio Prevalence medicine Humans Family Poisson regression Family history Medical History Taking Depression (differential diagnoses) Aged Depressive Disorder Major business.industry Family aggregation Odds ratio Middle Aged medicine.disease United States 030227 psychiatry Black or African American Psychiatry and Mental health Clinical Psychology Logistic Models Case-Control Studies Relative risk symbols Regression Analysis Major depressive disorder Female business 030217 neurology & neurosurgery |
Zdroj: | Depression and Anxiety. 35:674-684 |
ISSN: | 1091-4269 |
Popis: | Background African Americans (AAs) with major depressive disorder (MDD) experience more impairment and poorer treatment outcomes relative to Whites, yet are underrepresented in family studies of MDD. This is the first study to investigate the familial aggregation of major depression among AAs. Methods Participants' reports of depression from clinical and family history (FH) interviews were used to examine depression rates among 435 first-degree relatives and half-siblings of 63 depressed cases and 222 relatives of 33 nondepressed controls. Binary logistic regression was used to compute odds ratios (ORs) for FH of MDD and level of trauma exposure (high and low) in cases versus controls. Poisson regression models with generalized estimating equations were used to assess MDD in relatives of cases versus relatives of controls. Results Cases and controls did not differ in either FH of MDD (OR = 1.2, 95% confidence interval [CI] = 0.5-2.9), or prevalence of MDD in relatives (relative risk [RR] = 1.5, 95% CI = 0.8-2.5). However, exposure to high trauma was associated with increased risk of MDD (OR = 3.0, 95% CI = 1.22-7.17) and the combined effect of FH and trauma was greater than expected under an additive model. Similarly, the RR for MDD among relatives of cases with high-trauma levels was 2.2 (1.24-4.2), compared to relatives of controls with low trauma. Conclusion The effect of FH of MDD appears to be exacerbated among individuals exposed to high trauma. Replication and further research on the chronology and subtypes of trauma and MDD, and their interactions, remain essential in AA populations. |
Databáze: | OpenAIRE |
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