Self-Deliverable Peptide-Mediated and Reactive-Oxygen-Species-Amplified Therapeutic Nanoplatform for Highly Effective Bacterial Inhibition

Autor:	Rong Huang, Qi-Hang Yu, Xue-Di Yao, Wen-Long Liu, Yin-Jia Cheng, Yi-Han Ma, Ai-Qing Zhang, Si-Yong Qin
Rok vydání:	2021
Předmět:	Lipid Peroxides Mice Inbred BALB C Staphylococcus aureus Singlet Oxygen Anti-Bacterial Agents Linoleic Acids Drug Design Escherichia coli Animals Nanoparticles Female Staphylococcal Skin Infections General Materials Science Antimicrobial Cationic Peptides
Zdroj:	ACS Applied Materials & Interfaces. 14:159-171
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.1c17271
Popis:	An "antibiotic-free strategy" provides a viable option to address bacterial infections, especially for the "superbug" challenge. However, the undesirable antibacterial activity of antibiotic-free agents hinders their practical applications. In this study, we developed a combination antibacterial strategy of coupling peptide-drug therapy with chemodynamic therapy (CDT) to achieve the effective bacterial inhibition. An amphiphilic oligopeptide (LAOOH-OPA) containing a therapeutic unit of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc40f8e639086da7004398439129266c https://doi.org/10.1021/acsami.1c17271 Zobrazit plný text záznamu