Eosinophilia in Pleural Effusions: a Speculative Negative Predictor for Malignancy
| Autor: | Fang-Yeh Chu, Tzung-Hai Yen, Yun-Chieh Yu, Tse-Hsuan Liou, N-Chi Tan, Ming-Jang Su, Chih-Chun Chang, Chia-Hao Bei, Jen-Tang Sun, Ching-Biau Liou |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Epidemiology Pleural effusion medicine.medical_treatment Taiwan Thoracentesis Malignancy Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine Eosinophilia Eosinophilic Humans Medicine 030212 general & internal medicine Lung cancer Aged Lung business.industry Public Health Environmental and Occupational Health Middle Aged respiratory system Prognosis medicine.disease Transudate respiratory tract diseases Pleural Effusion medicine.anatomical_structure ROC Curve 030228 respiratory system Oncology Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 17:1411-1414 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2016.17.3.1411 |
| Popis: | Background Eosinophilic pleural effusion (EPE) is an eosinophil count more than 10% on cytology of pleural samples. Recently, it was reported that malignancy had been the most prevalent cause inducing EPE. Therefore, we conducted an analysis on the prevalence and etiology of EPE and investigated the relationship between EPE and malignancy. Materials and methods Data for pleural cell differential count from patients receiving thoracentesis during the period from January 2008 to December 2013 were compared with clinical data and established diagnosis of patients obtained via electronic chart review. Results A total of 6,801 requests of pleural cytology from 3,942 patients with pleural effusion who had received thoracentesis were available at Far Eastern Memorial Hospital from 2008 to 2013, and of these subjects, 115 (2.9%) were found to have EPE. The most frequent cause of EPE was malignancy (33.0%, n=38), followed by parapneumonic effusions (27.8%, n=32), tuberculosis pleuritis (13.9%, n=16), transudate effusions (12.2%, n=14) and the presence of blood or air in pleural space (10.4%, n=12). Additionally, an inverse relationship of eosinophilia in pleural fluid was identified in patients with malignancy and EPE. The cut-off eosinophil count in pleural fluid was 15% for the most accurate discrimination between malignancy and benign disorders in patients with EPE. At the cut-off level, the sensitivity and specificity were 65.8% and 67.5%, respectively. Conclusions Pleural fluid eosinophilia was a speculative negative predictor for malignancy, despite the fact that cancers, including lung cancers and metastatic cancers to lung, were the most leading cause of pleural fluid eosinophilia. An inverse correlation was observed between the pleural eosinophil percentage and the likelihood of malignancy in patients with EPE. |
| Databáze: | OpenAIRE |
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