The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
| Autor: | J. Caviedes-Bucheli, JO. Moreno, M. Aranguren-Carrero, S. Buitrago-Rojas, R. Lopez-Matheus, G. Martinez-Corredor, L. Díaz-Barrera, H. Muñoz-Alvear, J. Gomez-Sosa, H. Munoz |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Caviedes-Bucheli, J., Moreno, J. O., Aranguren-Carrero, M., Buitrago-Rojas, S., Lopez-Matheus, R., Martinez-Corredor, G., Díaz-Barrera, L. E., Muñoz-Alvear, H. D., Gomez-Sosa, J. F., & Munoz, H. R. (2022). The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp. Journal of clinical and experimental dentistry, 14(11), e932–e937. |
| ISSN: | 1989-5488 |
| Popis: | The purpose of this study was to quantify the effect of moderate and severe orthodontic forces on Calcitonin gene-related peptide (CGRP) expression in the healthy human periodontal ligament (PDL) and its possible relationship with the human dental pulp.Ninety human periodontal ligament samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons. Prior to extraction, teeth were divided in 3 groups of 30 samples each: I) Untreated teeth control group; II) Moderate force group: A 56 g force was applied to the premolars for 24 hours; and III) Severe force group: A 224 g force was applied to the premolars for 7 days. All periodontal ligament samples were processed and CGRP was measured by radioimmunoassay.Greater CGRP expression was found in the severe force group, followed by the moderate force group. The lower CGRP values were for the untreated teeth. Kruskal-Wallis test showed statistically significant differences between groups (CGRP expression in human periodontal ligament increases when teeth are submitted to severe orthodontic forces. This elevated expression of CGRP, which is proportional to the applied force, may affect the way the dental pulp responds to different stimuli from the orthodontic forces. |
| Databáze: | OpenAIRE |
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