Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1

Autor: Biewenga, Maaike, Verhelst, Xavier P. D. M. J., Baven-Pronk, Martine A. M. C., Putter, Hein, van den Berg, Aad P., van Nieuwkerk, Karin C. M. J., van Buuren, Henk R., Bouma, Gerd, de Boer, Ynte S., Simoen, Cedric, Colle, Isabelle, Schouten, Jeoffrey, Sermon, Filip, van Steenkiste, Christophe, van Vlierberghe, Hans, van der Meer, Adriaan J., Nevens, Frederik, van Hoek, Bart, Drenth, J. P. H., van Gerven, N. M., Beuers, U., van Erpecum, K. J., den Ouden, J. W., Bhalla, A., Brouwer, J. T., Vrolijk, J. M., Koek, G. H., Guichelaar, M. M. J., van der Wouden, E. J., van Meyel, J. J. M., Baak, L. C., Verdonk, R. C., Klemt-Kropp, M., Verhagen, M. A. M. T., Kuijvenhoven, J., de Jonge, H. M.
Přispěvatelé: Amsterdam Gastroenterology Endocrinology Metabolism, AII - Inflammatory diseases, Gastroenterology and hepatology, Gastroenterology & Hepatology, Groningen Institute for Organ Transplantation (GIOT), Dutch Autoimmune Hepatitis Study Group, Neurosurgery, ANS - Neurovascular Disorders, Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Liver Cirrhosis
Male
Cirrhosis
Time Factors
IMPACT
medicine.medical_treatment
Autoimmune hepatitis
risk stratification
Liver transplantation
Gastroenterology
THERAPY
DISEASE
Cohort Studies
Belgium
AIH
Interquartile range
Risk Factors
Medicine and Health Sciences
Child
CIRRHOSIS
transplant‐free survival
Netherlands
risk
Aged
80 and over
validation
OUTCOMES
liver transplantation
Hazard ratio
autoimmune liver disease
Middle Aged
Prognosis
prognostic score
Hepatitis
Autoimmune
Oncology
Child
Preschool
Cohort
Disease Progression
Original Article
Female
TRIAL
Life Sciences & Biomedicine
long-term survival
Adult
medicine.medical_specialty
Adolescent
long‐term survival
liver
Risk Assessment
Disease-Free Survival
Decision Support Techniques
Young Adult
stratification
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Humans
Aged
Proportional Hazards Models
Science & Technology
Gastroenterology & Hepatology
autoimmune hepatitis
business.industry
Proportional hazards model
Reproducibility of Results
NATURAL-HISTORY
REMISSION
medicine.disease
mortality
transplant-free survival
Transplantation
Multivariate Analysis
Human medicine
Hepatobiliary
business
transplantation
Zdroj: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
Dutch Autoimmune Hepatitis Study group 2021, ' Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1 ', United European Gastroenterology Journal, vol. 9, no. 6, pp. 662-671 . https://doi.org/10.1002/ueg2.12112
United European Gastroenterology Journal, 9(6), 662-671. SAGE Publications Inc.
United European Gastroenterology Journal, 9(6), 662-671. SAGE Publishing
United European Gastroenterology Journal, 9(6), 662-671. SAGE PUBLICATIONS INC
United European Gastroenterology Journal
United European gastroenterology journal
United European gastroenterology journal, 9(6), 662-671. SAGE Publications Inc.
ISSN: 2050-6406
2050-6414
DOI: 10.1002/ueg2.12112
Popis: BACKGROUND: No prognostic score is currently available for long-term survival in autoimmune hepatitis (AIH) patients. OBJECTIVE: The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. METHODS: The prognostic score was developed using uni- & multivariate Cox regression in a 4-center Dutch cohort and validated in an independent 6-center Belgian cohort. RESULTS: In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow-up 118 months; interquartile range 60-202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p
Databáze: OpenAIRE
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