A 1D model of the arterial circulation in mice
| Autor: | Rodrigo A. Fraga-Silva, Lydia Aslanidou, Patrick Segers, Philippe Reymond, Bram Trachet, Nikolaos Stergiopulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty Pathology X-ray microtomography contrast-enhanced micro-CT Arteries/anatomy & histology/physiology Animal Testing Alternatives Inbred C57BL Cardiovascular Mice In vivo Pressure waveform Models Internal medicine 1D mouse model Medicine Animals Computer Simulation ventricular-vascular coupling Pulse wave velocity Ultrasonography Pharmacology Ultrasonography Doppler Duplex X-Ray Microtomography/methods business.industry Animal Models Cardiovascular Doppler Arteries X-Ray Microtomography General Medicine Blood flow high-frequency ultrasound Arterial tree Duplex Mice Inbred C57BL Medical Laboratory Technology Models Animal Cardiology Aortic stiffness systemic arterial tree business Algorithms |
| Zdroj: | ALTEX, Vol. 33, No 1 (2016) pp. 13-28 |
| ISSN: | 1868-596X |
| Popis: | At a time of growing concern over the ethics of animal experimentation, mouse models are still an indispensable source of insight into the cardiovascular system and its most frequent pathologies. Nevertheless, reference data on the murine cardiovascular anatomy and physiology are lacking. In this work, we developed and validated an in silico, one dimensional model of the murine systemic arterial tree consisting of 85 arterial segments. Detailed aortic dimensions were obtained in vivo from contrast-enhanced micro-computed tomography in 3 male, C57BL/6J anesthetized mice and 3 male ApoE(-/-) mice, all 12-weeks old. Physiological input data were gathered from a wide range of literature data. The integrated form of the Navier-Stokes equations was solved numerically to yield pressures and flows throughout the arterial network. The resulting model predictions have been validated against invasive pressure waveforms and non-invasive velocity and diameter waveforms that were measured in vivo on an independent set of 47 mice. In conclusion, we present a validated one-dimensional model of the anesthetized murine cardiovascular system that can serve as a versatile tool in the field of preclinical cardiovascular research. |
| Databáze: | OpenAIRE |
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