Routine laboratory parameters predict serious outcome as well as length of hospital stay in COVID-19
| Autor: | Moayad A Haddad, Mohammed B Albarqi, Mohammed A. Jeraiby, Rehab I Areda, Johar Iqbal, Majed I Hakamy |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Neutrophils Logistic regression Gastroenterology Internal medicine Medicine Humans Lymphocytes Risk factor Retrospective Studies biology Mean corpuscular hemoglobin concentration medicine.diagnostic_test Receiver operating characteristic business.industry SARS-CoV-2 fungi C-reactive protein COVID-19 Retrospective cohort study Red blood cell distribution width General Medicine Odds ratio Length of Stay Prognosis biology.protein business Laboratories |
| Zdroj: | Saudi medical journal. 42(11) |
| ISSN: | 0379-5284 |
| Popis: | Objectives To validate C-reactive protein (CRP), red cell distribution width (RDW), and neutrophil lymphocyte ratio (NLR) for both serious outcomes and length of hospital stay (LOS) among hospitalized coronavirus disease-19 (COVID-19) patients. Methods Laboratory data of adult COVID-19 patients (n=74) was collected in this retrospective cohort. Logistic regression was employed for risk factor evaluation and receiver operating curve was used for comparison of these risk factors for the prediction of serious outcome. Multiple regression was applied to determine the association between routine analytes and LOS. Results Higher levels of CRP (3 times), white blood cells (20%), and neutrophil counts (40%) were seen in the serious category. Odds ratio for CRP for the serious outcome was 1.052 (p=0.007) and RDW for the serious outcome was 1.218 (p=0.040) in unadjusted model and odds ratio for CRP for the serious outcome was 1.048 (p=0.024) and for RDW 1.286 (p=0.023) in adjusted model. In a multivariate regression analysis for the LOS of the unadjusted models consisting of NLR, monocyte lymphocyte ratio (MLR) and platelet lymphocyte ratio (PLR), the beta coefficients (BC) for the CRP were 0.006 (NLR), 0.005 (MLR) and 0.006 (PLR), whereas -0.029 (NLR), -0.034 (MLR) and -0.027 (PLR) were BCs for mean corpuscular hemoglobin concentration (MCHC). Additionally, in adjusted models, the BCs for MCHC were -0.044 (NLR), -0.047 (MLR) and -0.043 (PLR). However, the CRP was consistent with 0.004 (BC) in all models. Conclusion We observed that CRP is a better predictor than RDW and NLR for serious outcome among COVID-19 patients. Besides, CRP was positively, whereas MCHC was negatively associated with LOS. |
| Databáze: | OpenAIRE |
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