Effect of grade on disease-free survival and overall survival in FIGO stage I adenocarcinoma of the endometrium
| Autor: | Alexandre Megalo, Philippe Coucke, Sandro Pampallona, Pierre De Grandi, Jean Francois Delaloye |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Brachytherapy Adenocarcinoma Endometrium Gastroenterology Metastasis Internal medicine medicine Overall survival Humans Stage (cooking) Aged Proportional Hazards Models Aged 80 and over Gynecology business.industry Incidence Hazard ratio Obstetrics and Gynecology Cell Differentiation Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Endometrial Neoplasms Radiation therapy medicine.anatomical_structure Reproductive Medicine Female business |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 88:75-80 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/s0301-2115(99)00124-4 |
| Popis: | Objective: To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods: From 1979 to 1995, 350 patients with FIGO stage IA–IC with well (G1), moderately (G2) or poorly (G3) differentiated tumors were treated with surgery and high dose-rate brachytherapy with or without external radiation. Median age was 65 years (39–86 years). Results: The 5-year DFS was 88±3% for the G1 tumors, 77±4% for the G2 tumors, and 67±7% for the G3 tumors (P=0.0049). With regard to the events contributing to DFS, the 5-year cumulative percentage of local relapse was 4.6% for the G1 tumors, 9.0% for the G2 tumors, and 4.6% (P=0.027) for the G3 tumors. Cumulative percentage of metastasis was 1.4, 6.3 and 7.2% (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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