Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species
| Autor: | João Quevedo, George González Ortega, Eloir Paulo Schenkel, Grace Gosmann, Flávio Henrique Reginatto, Raquel Denise Petry, Fernanda de-Paris |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.drug_class Passifloraceae Drug Compounding Administration Oral Pharmacognosy Anxiolytic law.invention Passiflora law medicine Animals Rats Wistar Maze Learning Pharmacology Folk medicine Spray dried Drug compounding biology Traditional medicine Behavior Animal Dose-Response Relationship Drug Chemistry Plant Extracts biology.organism_classification Rats Plant Leaves Anti-Anxiety Agents Medicine Traditional Phytotherapy Brazil |
| Zdroj: | Phytotherapy research : PTR. 20(5) |
| ISSN: | 0951-418X |
| Popis: | The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray-dried powders obtained from P. alata and P. edulis, known in Brazil as 'maracuja'. Male adult Swiss rats were treated with 200, 400 and 800 mg/kg of spray-dried powders p.o. and anxiolytic activity was evaluated using the elevated plus-maze test. The spray-dried powders showed anxiolytic activity in doses of 400 and 800 mg/kg. Our results support the potential anxiolytic effect of Passiflora spray-dried powders (P. alata and P. edulis). |
| Databáze: | OpenAIRE |
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