Ipragliflozin as an Initial Therapy in Drug Naïve Subjects with Type 2 Diabetes
| Autor: | A. Wada, T. Murayama, M. Hirate, Eiji Kutoh |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty 030209 endocrinology & metabolism Thiophenes Type 2 diabetes Pharmacology 030226 pharmacology & pharmacy Body Mass Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Glucosides Piperidines Internal medicine Drug Discovery medicine Humans Hypoglycemic Agents Prospective Studies Uracil Adverse effect Glycated Hemoglobin Glycemic efficacy business.industry General Medicine Middle Aged medicine.disease Drug-naïve Ipragliflozin Diabetes Mellitus Type 2 chemistry Tolerability Female business Alogliptin medicine.drug |
| Zdroj: | Drug Research. 66:345-350 |
| ISSN: | 2194-9387 2194-9379 |
| Popis: | The aim of this study is to investigate ipragliflozin as an initial type 2 diabetes (T2DM) drug.Ipragliflozin 25-50 mg/day monotherapy was performed with drug naïve subjects with T2DM (n=31). As a comparator, 12.5-25 mg/day alogliptin monotherapy was undertaken (n=32). At 3 months, levels of metabolic parameters were compared with those at baseline.4 subjects discontinued ipragliflozin due to intolerance or adverse events, while none dropped out with alogliptin. At 3 months, similar decreases of HbA1c levels were observed with these 2 drugs (10.21-8.31%, p0.00001, with ipragliflozin, and 10.08-8.25%, p0.00001, with alogliptin), however fasting blood glucose (FBG) levels decreased with significant inter-group differences (- 23.5% with iprgliflozin and - 10.8% with alogliptin). While similar increases of homeostasis model assessment (HOMA)-B levels were observed with these 2 drugs, HOMA-R levels significantly decreased only with ipragliflozin (-19.4%, p0.02). Un-correlative link between HOMA-R and HOMA-B levels at baseline became significantly correlative (R=0.6017, p0.001) only with ipragliflozin. Significant reductions of body mass index (BMI, -2.6%, P0.05) were observed with ipragliflozin, however, no correlations between the changes of BMI and those of HbA1c or FBG were noted.These results suggest that ipragliflozin has good glycemic efficacy as an initial therapy in subjects with T2DM, although certain adverse events or tolerability issues are concerned. It improves insulin sensitivity and may restore the impaired beta-cell function. However body weight reduction with ipragliflozin is not associated with its glycemic efficacy. |
| Databáze: | OpenAIRE |
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