Case—Control Studies of Cardiovascular Medications as Risk Factors for Clinically Diagnosed Depressive Disorders in a Hospitalized Population
| Autor: | Scott B. Patten, Edgar J. Love, Jeanne V.A. Williams |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Angiotensin-Converting Enzyme Inhibitors Patient Admission Risk Factors Internal medicine Epidemiology Odds Ratio Humans Medicine education Depression (differential diagnoses) Aged Aged 80 and over Heart Failure Depressive Disorder education.field_of_study business.industry Case-control study Cardiovascular Agents Odds ratio Middle Aged medicine.disease Surgery Psychiatry and Mental health Mood disorders Cardiovascular Diseases Case-Control Studies Hypertension ACE inhibitor Etiology Female business medicine.drug |
| Zdroj: | The Canadian Journal of Psychiatry. 41:469-476 |
| ISSN: | 1497-0015 0706-7437 |
| DOI: | 10.1177/070674379604100713 |
| Popis: | Objective: Certain medications used in cardiovascular therapeutics may contribute to the etiology of substance-induced mood disorders. These medications include digoxin, angiotensin converting enzyme (ACE) inhibitors, β- blockers, and calcium channel blockers. The objective of this study was to evaluate associations between these drugs and clinical diagnoses of depressive disorders in a population of hospitalized patients. Method: Two case–control studies were conducted. For each study, subjects were selected from a health records data base maintained at the Calgary General Hospital. Selection of subjects in the first study was restricted to those receiving a discharge diagnosis of congestive heart failure and in the second study to subjects receiving a discharge diagnosis of hypertension. In each of these 2 studies, a single case group was selected along with 2 control groups: a psychiatric control group consisting of subjects receiving a psychiatric diagnosis other than a depressive disorder and a nonpsychiatric control group receiving no psychiatric diagnoses. Drug exposures and other variables were recorded from a chart review. Results: Exposures to digoxin, β- blockers, and calcium channel blockers were not associated with depressive diagnoses. An association was observed, however, for ACE inhibitors. An elevated odds ratio (OR) was observed in each case-control study and was stronger infernale subjects and subjects over the age of 65. Conclusions: This is the first reported epidemiological evidence of an association between ACE inhibitors and depressive disorders. The design of this study does not permit a determination of whether the observed association was causal. Additional studies are needed. |
| Databáze: | OpenAIRE |
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