Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
| Autor: | Oliver J. Rando, Fengyun Sun, Emiliano P. Ricci, Clémence Belleannée, Lucas Fauquier, Manuel Garber, Ryan W. Serra, Ana Bošković, Xin Zhiguo Li, Xin Y. Bing, Benjamin R. Carone, Lina Song, Craig C. Mello, Melissa J. Moore, Alper Kucukural, Alan G. Derr, Jeremy M. Shea, Robert Sullivan, Colin C. Conine, Upasna Sharma |
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| Přispěvatelé: | Conseil National de Recherches Canada (CNRC), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Faculté de Médecine, Centre Hospitalier de l'Université de Laval (CHUL), Istituto Nazionale di Fisica della Materia, Dipartimento di Scienza dei Materiali, Key Laboratory of Ocean Circulation and Waves, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China, Université Paris Diderot - Paris 7 (UPD7), Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Broad Institute [Cambridge], Harvard University-Massachusetts Institute of Technology (MIT), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard University [Cambridge]-Massachusetts Institute of Technology (MIT), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Small RNA endocrine system Retroelements [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Article 03 medical and health sciences Mice Testis medicine Diet Protein-Restricted Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Gene reproductive and urinary physiology Genetics Regulation of gene expression Epididymis Multidisciplinary urogenital system RNA Embryo RNA Transfer Gly Sperm Spermatozoa Cell biology Sperm Maturation MicroRNAs 030104 developmental biology medicine.anatomical_structure Blastocyst Gene Expression Regulation Fertilization Transfer RNA |
| Zdroj: | Science Science, 2016, 351 (6271), pp.391-396. ⟨10.1126/science.aad6780⟩ Science, American Association for the Advancement of Science, 2016, 351 (6271), pp.391-396. ⟨10.1126/science.aad6780⟩ |
| ISSN: | 0036-8075 1095-9203 |
| Popis: | Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen et al. injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and concomitant alteration of genes in metabolic pathways. Sharma et al. observed the biogenesis and function of small tRNA-derived fragments during sperm maturation. Further understanding of the mechanisms by which progeny are affected by parental exposure may affect human diseases such as diet-induced metabolic disorders. Science , this issue p. 397 , p. 391 |
| Databáze: | OpenAIRE |
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