MitoQ supplementation prevent long-term impact of maternal smoking on renal development, oxidative stress and mitochondrial density in male mice offspring
Autor: | Ewa M. Goldys, Yik Lung Chan, Sonia Saad, Amgad Zaky, Hui Chen, Razia Zakarya, Carol A. Pollock, Rachana Santiyanont, Suporn Sukjamnong, Ayad G. Anwer, Brian G. Oliver |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male Offspring Ubiquinone Receptor for Advanced Glycation End Products lcsh:Medicine Physiology Fluorescent Antibody Technique medicine.disease_cause Kidney Article 03 medical and health sciences chemistry.chemical_compound Mice Organophosphorus Compounds Pregnancy medicine Animals lcsh:Science MitoQ Multidisciplinary 030102 biochemistry & molecular biology business.industry lcsh:R Smoking Kidney metabolism medicine.disease Mitochondria Oxidative Stress 030104 developmental biology medicine.anatomical_structure Renal pathology chemistry Maternal Exposure Prenatal Exposure Delayed Effects Dietary Supplements lcsh:Q Female Inflammation Mediators business Oxidative stress Biomarkers Kidney disease Signal Transduction |
Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
ISSN: | 2045-2322 |
Popis: | To investigate the effect of maternal MitoQ treatment on renal disorders caused by maternal cigarette smoke exposure (SE). We have demonstrated that maternal SE during pregnancy increases the risk of developing chronic kidney disease (CKD) in adult offspring. Mitochondrial oxidative damage contributes to the adverse effects of maternal smoking on renal disorders. MitoQ is a mitochondria-targeted antioxidant that has been shown to protect against oxidative damage-related pathologies in many diseases. Female Balb/c mice (8 weeks) were divided into Sham (exposed to air), SE (exposed to cigarette smoke) and SEMQ (exposed to cigarette smoke with MitoQ supplemented from mating) groups. Kidneys from the mothers were collected when the pups weaned and those from the offspring were collected at 13 weeks. Maternal MitoQ supplementation during gestation and lactation significantly reversed the adverse impact of maternal SE on offspring’s body weight, kidney mass and renal pathology. MitoQ administration also significantly reversed the impact of SE on the renal cellular mitochondrial density and renal total reactive oxygen species in both the mothers and their offspring in adulthood. Our results suggested that MitoQ supplementation can mitigate the adverse impact of maternal SE on offspring’s renal pathology, renal oxidative stress and mitochondrial density in mice offspring. |
Databáze: | OpenAIRE |
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