Biomarkers of response to preoperative chemoradiation in esophageal cancers
| Autor: | Jaffer A. Ajani, Madan G. Luthra, Li Zhang, Rajyalakshmi Luthra, In Seon Choi, Usha Malhotra, Enrique Lopez-Alvarez, Tsung Teh Wu, Julie G. Izzo |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Esophageal Neoplasms medicine.medical_treatment Treatment outcome Antineoplastic Agents Adenocarcinoma Internal medicine Expression analysis medicine Biomarkers Tumor Humans Oligonucleotide Array Sequence Analysis Preoperative chemoradiotherapy Chemotherapy Radiotherapy Esophageal disease business.industry Gene Expression Profiling Cancer Hematology Esophageal cancer medicine.disease Combined Modality Therapy Radiation therapy Gene Expression Regulation Neoplastic Carcinoma Squamous Cell business |
| Zdroj: | Seminars in oncology. 33(6 Suppl 11) |
| ISSN: | 0093-7754 |
| Popis: | To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients had pathologic complete response. All cancers except one that achieved pathologic complete response (83%) clustered in one molecular type (type I), while cancers that achieved less than pathologic complete response with one exception clustered in another molecular type (type II). Activated NF-kappaB was significantly associated with aggressive pathology. These data indicate that expression analysis of a limited set of biomarkers selected from the list of genes that were differentially regulated between the two subtypes can increase predictive power, and suggest that esophageal cancer with activated NF-kappaB may result in poor treatment outcome. |
| Databáze: | OpenAIRE |
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