Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke
| Autor: | I. A. Prudchenko, I. I. Mikhaleva, Elvira R. Shaykhutdinova, O. N. Khokhlova, G. A. Slashcheva, Vadim T. Ivanov, Elena A Tukhovskaya, Alina M Ismailova, Arkady N. Murashev |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pharmaceutical Science Infarction Organic chemistry Motor Activity Motor function DSIP Article Analytical Chemistry Rats Sprague-Dawley QD241-441 Delta Sleep-Inducing Peptide Drug Discovery Occlusion Animals Medicine cardiovascular diseases Physical and Theoretical Chemistry Stroke Bilateral asymmetry business.industry motor function Brain Electroencephalography Infarction Middle Cerebral Artery medicine.disease stroke Motor coordination rats Disease Models Animal Chemistry (miscellaneous) Rotarod Performance Test Anesthesia Molecular Medicine Delta sleep-inducing peptide Nasal administration business |
| Zdroj: | Molecules Volume 26 Issue 17 Molecules, Vol 26, Iss 5173, p 5173 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26175173 |
| Popis: | Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions. |
| Databáze: | OpenAIRE |
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