Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study
| Autor: | Géraldine Jacquemin, Bernard E. Leduc, Christine Fournier, Pierre-Olivier Hétu, Yves Lepage, Miguel Chagnon, Bernard Vinet |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male business.industry Ejaculation Midodrine Middle Aged Placebo medicine.disease Double blind Oral administration Anesthesia Humans Medicine In patient Adrenergic alpha-1 Receptor Agonists Neurology (clinical) Genital Diseases Male business Spinal cord injury Spinal Cord Injuries Research Articles Anejaculation medicine.drug |
| Zdroj: | The Journal of Spinal Cord Medicine. 38:57-62 |
| ISSN: | 2045-7723 1079-0268 |
| DOI: | 10.1179/2045772314y.0000000225 |
| Popis: | The objective of this study is to evaluate the efficacy of midodrine in the treatment of anejaculation in men with spinal cord injury (SCI).Prospective, double-blind, randomized, placebo-controlled pilot study.Men with anejaculation associated with SCI (level of injury above T10) of more than 1 year in duration were approached. Those with no ejaculatory response to one penile vibratory stimulation (PVS) trial were assigned in a double-blind manner to one of the two following interventions once a week for a maximum of 3 weeks or until ejaculation occurred: oral administration of flexible midodrine (7.5-22.5 mg max) followed by PVS (group M), or oral administration of flexible sham-midodrine (placebo) followed by PVS (group P). Sociodemographic data, medical characteristics, and plasma desglymidodrine concentration were collected for all participants.Ejaculation success rate in each group.Among the 78 men approached, 23 participants (level of SCI: C4-T9) were randomized. Three participants abandoned the study and 20 completed the study; 10 were assigned to group M, 10 to group P. Ejaculation was reached for one participant of group M and for two participants of group P. Autonomic dysreflexia associated to PVS occurred in three patients.In this small sample study, treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS. |
| Databáze: | OpenAIRE |
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