On the use of Functionally Graded Materials to differentiate the effects of surface severe plastic deformation, roughness and chemical Composition on cell proliferation
| Autor: | Laurent Weiss, Marc Novelli, Yaël Nessler, Thierry Grosdidier, Pascal Laheurte |
|---|---|
| Přispěvatelé: | Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Labex DAMAS, Université de Lorraine (UL) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Biocompatibility surface mechanical attrition treatment (SMAT) Niobium chemistry.chemical_element 02 engineering and technology Surface finish human mesenchymal stem cells culture 01 natural sciences titanium niobium alloys 0103 physical sciences [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] General Materials Science Composite material [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials Chemical composition 010302 applied physics Metals and Alloys cell adhesion ultrasonic shot peening (USP) Adhesion [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Microstructure functionally graded materials (FGM) titanium molybdenum alloys cell proliferation chemistry [SDV.IB]Life Sciences [q-bio]/Bioengineering Severe plastic deformation 0210 nano-technology Titanium |
| Zdroj: | Metals Metals, MDPI, 2019, 9 (12), pp.1344. ⟨10.3390/met9121344⟩ Volume 9 Issue 12 |
| ISSN: | 2075-4701 |
| Popis: | International audience; Additive manufacturing allows the manufacture of parts made of functionally graded materials (FGM) with a chemical gradient. This research work underlines that the use of FGM makes it possible to study mechanical, microstructural or biological characteristics while minimizing the number of required samples. The application of severe plastic deformation (SPD) by surface mechanical attrition treatment (SMAT) on FGM brings new insights on a major question in this field: which is the most important parameter between roughness, chemistry and microstructure modification on biocompatibility? Our study demonstrates that roughness has a large impact on adhesion while microstructure refinement plays a key role during the early stage of proliferation. After several days, chemistry is the main parameter that holds sway in the proliferation stage. With this respect, we also show that niobium has a much better biocompatibility than molybdenum when alloyed with titanium. |
| Databáze: | OpenAIRE |
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