In vitro analysis of polyurethane foam as a topical hemostatic agent
| Autor: | Ferdinand I. Broekema, Rudolf R.M. Bos, Wim van Oeveren, Johan Zuidema, Susan H. Visscher |
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| Přispěvatelé: | Personalized Healthcare Technology (PHT) |
| Rok vydání: | 2011 |
| Předmět: |
THROMBIN TISSUE SEALANT
Materials science food.ingredient CROSS-LINKING Polymers Surface Properties Polyurethanes COAGULATION CASCADE Biomedical Engineering Biophysics Biocompatible Materials Hemorrhage Bioengineering Polyethylene glycol In Vitro Techniques Gelatin Antithrombins Hemostatics Article Polyethylene Glycols Biomaterials PARTIAL NEPHRECTOMY chemistry.chemical_compound food In vivo Materials Testing PEG ratio WHOLE-BLOOD Humans Composite material BLOOD-COAGULATION Blood Coagulation Polyurethane Hemostasis POLYETHYLENE Hemostatic Agent Thrombin PLATELET-ADHESION BLOCK-COPOLYMERS chemistry Chemical Engineering(all) Collagen GENERATION Biomedical engineering |
| Zdroj: | Journal of Materials Science-Materials in Medicine, 22(4), 1081-1086. SPRINGER Journal of Materials Science. Materials in Medicine |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-011-4276-9 |
| Popis: | Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has been evaluated and compared to commonly used agents. An experimental in vitro test model was used in which human blood flowed through the test material. Different modified polyurethane foams were compared to collagen and gelatin. The best coagulation was achieved with collagen. The results of the polyurethane foam improved significantly by increasing the amount of polyethylene glycol. Therefore, the increase of the PEG concentration seems a promising approach. Additional in vivo studies will have to be implemented to assess the application of polyurethane foam as a topical hemostatic agent. |
| Databáze: | OpenAIRE |
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