Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report

Autor:	Paolo Rosa, Giuseppe Giannini, Giuseppe Ragona, Vincenzo Petrozza, Luca Pacini, Antonella Calogero, Daniela Bastianelli, Donatella Ponti
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Histology Colorectal cancer DNA Mutational Analysis Cetuximab Locus (genetics) Biology Antibodies Monoclonal Humanized Biomarkers Pharmacological Pathology and Forensic Medicine medicine Biomarkers Tumor Mucinous carcinoma Humans Allele Protein Kinase Inhibitors Alleles EGFR inhibitors Aged Panitumumab Antibodies Monoclonal intra-tumor heterogeneity medicine.disease Phenotype Adenocarcinoma Mucinous Medical Laboratory Technology Genes ras colon cancer Drug Resistance Neoplasm RAS Mutation Colonic Neoplasms Mutation K-RAS mutations Cancer research Female Intracellular
Popis:	Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc344e74702a414abfcd54d48b58f986 http://hdl.handle.net/11573/783698 Zobrazit plný text záznamu