Improved posttransplant mortality after share 35 for liver transplantation
| Autor: | Aparna Goel, Ajitha Mannalithara, Allison J. Kwong, W. Ray Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Tissue and Organ Procurement Cirrhosis medicine.medical_treatment Kaplan-Meier Estimate 030230 surgery Liver transplantation Severity of Illness Index Cohort Studies End Stage Liver Disease 03 medical and health sciences Liver disease 0302 clinical medicine Cause of Death Internal medicine Severity of illness Humans Medicine Policy Making Aged Proportional Hazards Models Retrospective Studies Hepatology Proportional hazards model business.industry Health Policy Graft Survival Hazard ratio Retrospective cohort study Middle Aged medicine.disease Liver Transplantation Surgery body regions Transplantation Multivariate Analysis Female 030211 gastroenterology & hepatology business |
| Zdroj: | Hepatology. 67:273-281 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | Background and Aims: The Share 35 policy was implemented in June 2013 to improve equity in access to liver transplantation (LT) between patients with fulminant liver failure and those with cirrhosis and severe hepatic decompensation. The aim of this study was to assess post-LT outcomes after Share 35. Methods: Relevant donor, procurement, and recipient data were extracted from the OPTN/UNOS database. All adult deceased donor LT from January 1, 2010 to March 31, 2016 were included in the analysis. One-year patient survival before and after Share 35 was assessed by multivariable Cox proportional hazards analysis, with adjustment for variables known to affect graft survival. Results: Of 34,975 adult LT recipients, 16,472 (47.1%) were transplanted after the implementation of Share 35, of whom 4,599 (27.9%) had a Model for End-Stage Liver Disease (MELD) ≥35. One-year patient survival improved from 83.9% to 88.4% after Share 35 (p |
| Databáze: | OpenAIRE |
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