Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder
| Autor: | Maulik P. Shah, Andrés Martin, Monique M. Jones, Brian Pittman, Fei Wang, Jessica H. Kalmar, Hilary P. Blumberg, Lara G. Chepenik, R. Todd Constable, Fay Y. Womer |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Bipolar Disorder Adolescent Emotions Statistics as Topic Brain mapping Amygdala Article Arousal Neuroimaging Basal ganglia Image Processing Computer-Assisted Developmental and Educational Psychology medicine Humans Bipolar disorder Child Dominance Cerebral Brain Mapping Facial expression medicine.diagnostic_test Organ Size medicine.disease Magnetic Resonance Imaging Facial Expression Psychiatry and Mental health medicine.anatomical_structure Pattern Recognition Visual Female Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Journal of the American Academy of Child & Adolescent Psychiatry. 48:636-642 |
| ISSN: | 0890-8567 |
| DOI: | 10.1097/chi.0b013e31819f6fbc |
| Popis: | Objective Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging scans were obtained during the same neuroimaging session to examine amygdala structure-function relations in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response. Method Fifty-one adolescents (21 with BD I and 30 control adolescents, ages 10-18 years) underwent structural and functional magnetic resonance imaging scans. Amygdala volume ( n = 49) and signal change ( n = 44) during emotional face processing were compared between groups, and structure-function correlations were examined within the BD group ( n = 16). Results Adolescents with BD showed decreased amygdala volume ( p = .009) and increased amygdala response to emotional faces ( p = .043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed ( r = −0.54, p = .029). Conclusions Decreased volume and increased response to emotional stimuli in the amygdala in adolescents with BD are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relation characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD. J. Am. Acad. Child Adolesc. Psychiatry ,2009;48(6):636-642. |
| Databáze: | OpenAIRE |
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