Influenza vaccine effectiveness and confounding factors among young children
| Autor: | Kyoko Kondo, Masaro Kaji, Akiko Maeda, Yoshio Hirota, Satoko Ohfuji, Megumi Fujieda, Wakaba Fukushima |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Confounding Factors (Epidemiology) Influenza vaccine Subgroup analysis Logistic regression Disease Outbreaks Japan Risk Factors Influenza Human Humans Medicine Child General Veterinary General Immunology and Microbiology business.industry Vaccination Confounding Age Factors Public Health Environmental and Occupational Health Infant Confounding Factors Epidemiologic Odds ratio Treatment Outcome Infectious Diseases El Niño Influenza Vaccines Child Preschool Molecular Medicine Female business |
| Zdroj: | Vaccine. 26:6481-6485 |
| ISSN: | 0264-410X |
| Popis: | This study, done during the 2002--2003 season among children6 years of age to investigate influenza vaccine effectiveness and confounding factors, involved 2913 children (1512 vaccinees, 1401 non-vaccinees) recruited from 54 paediatric clinics. Between December 2002 and April 2003, parents reported their children's maximum body temperatures weekly. Influenza-like illness (ILI) was defined as an acute febrile illness (or =38.0 degrees C) during the peak epidemic period. Adjusted odds ratios (ORs) for ILI were obtained using a logistic regression model. In analysis for total subjects, the ORs were significantly decreased for vaccinees (OR: 0.76, 95% CI: 0.66-0.88) and significantly increased for younger age groups, including children aged 2.0-3.9 years (1.42, 1.18-1.72) and those2.0 years (2.02,1.61-2.54), compared to those between 4.0 and 5.9 years. ORs were significantly increased for children who visited a physician within the last 6 months for a cold (1.27, 1.08-1.50), attended preschool (1.72, 1.45-2.04), and hador =3 siblings (1.42, 1.15-1.74). These confounding factors are suggested to be considered in estimating vaccine effectiveness among young children. In subgroup analysis by age groups, significantly decreased ORs were seen in 2.0-3.9-year-old (0.59, 0.47-0.74) and 4.0-5.9-year-old (0.75, 0.58-0.98) vaccinees; no significant vaccine effectiveness was detected for those2.0 years (1.07, 0.80-1.44). Thus, among very young children vaccine effectiveness could not be demonstrated. |
| Databáze: | OpenAIRE |
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