Effect of levamisole on active antibody titres and histomorphometric parameters of immune organs in broiler chickens
| Autor: | A. S. Zandi, R. Akbarian, S. Hamedi, T. Shomali, S. Sadeghi |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty animal structures 040301 veterinary sciences animal diseases Biology digestive system 0403 veterinary science Caecum Immune system medicine lcsh:Veterinary medicine General Veterinary digestive oral and skin physiology 0402 animal and dairy science Broiler Histology 04 agricultural and veterinary sciences Levamisole biology.organism_classification 040201 dairy & animal science Bursa Fabricii Immunology Ultrastructure biology.protein lcsh:SF600-1100 Antibody medicine.drug |
| Zdroj: | Bulgarian Journal of Veterinary Medicine, Vol 20, Iss 2, Pp 174-182 (2017) |
| ISSN: | 1313-3543 1311-1477 |
| Popis: | Use of immunomodulators has increased, particularly in poultry production around the world. The study evaluates effect of levamisole HCl (LMS) as an immunostimulatory agent on antibody titres and histomorphometric parameters of caecal tonsils, bursa and thymus of broilers. Sixty chickens were treated with 0 (control), 2, 5, 10, 15 and 25 mg/kg LMS in drinking water for 45 days. Antibody titre against ND, AI, IBD and IB was assayed periodically. At the end of the experiment, histological sec-tions were made from caecal tonsils, bursa and thymus. LMS had no effect on body, caecal tonsil and bursa weights. Treated birds, except those at 15 mg/kg, showed significantly higher antibody titres in some of the sampling occasions. In caecal tonsils, the highest dose had the most remarkable effect. In bursa, the most profound effect of this dose was on number of follicles per plica. Thymus was the least affected organ. In conclusion, LMS administration affected positively active antibody titres and histomorphometric parameters of caecal tonsils, bursa and less profoundly thymus in normal broilers. |
| Databáze: | OpenAIRE |
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