| Autor: |
Toshihide Hirai, Hiroshi Kobayashi, Eisuke Kobayashi, Masanori Saito, Toru Akiyama, Kazutaka Kikuta, Takaaki Nakai, Makoto Endo, Shinji Tsukamoto, Michiyuki Hakozaki, Satoshi Takenaka, Shunji Nishimura, Hiroyuki Kawashima, Yoshikazu Tanzawa, Hirotaka Kawano, Sakae Tanaka |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International journal of clinical oncology. 27(11) |
| ISSN: |
1437-7772 |
| Popis: |
Low-grade osteosarcomas, namely parosteal osteosarcoma (POS) and low-grade central osteosarcoma (LGCOS), occasionally dedifferentiate into high-grade malignancy, referred to as dedifferentiation in low-grade osteosarcoma (DLOS). This study aimed to elucidate the clinicopathologic features of DLOS, which are poorly described to date due to the extreme rarity of the disease.A total of 33 patients with DLOS were included. Clinical characteristics, including the diagnostic accuracy of tumor biopsy, multimodal treatments, and clinical course, were retrospectively reviewed. Univariate analysis was performed to identify prognostic factors associated with overall survival (OS) and metastasis-free survival (MFS).The tumor subtypes comprised 10 cases (30.3%) of LGCOS and 23 cases (69.7%) of POS. The timing of dedifferentiation was synchronous in 25 (75.8%) and metachronous in 8 (24.2%) patients. The rates of preoperative diagnosis of DLOS were 40.0% and 65.4% for core needle biopsy and incisional biopsy, respectively. All patients underwent surgery and 25 patients received perioperative chemotherapy. Of the 13 patients who received neoadjuvant chemotherapy, 11 exhibited a poor histological response. The 5-year OS and MFS rates were 88.1% and 77.7%, respectively. Univariate analysis revealed that local recurrence was associated with poor OS (P 0.01) and MFS (P 0.01). Perioperative chemotherapy did not affect OS or MFS.The diagnostic accuracy of tumor biopsy for DLOS was lower than that for bone sarcomas, as reported previously. In contrast to conventional osteosarcomas with high chemosensitivity, both histological responses and survival analysis revealed low efficacy of chemotherapy for DLOS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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