Multiple sclerosis and amyotrophic lateral sclerosis: a human leukocyte antigen challenge
| Autor: | Dattola, Vincenzo, Famã , Fausto, Russo, Margherita, Calabrã², Rocco Salvatore, Logiudice, Anna Lisa, Grasso, Maria Grazia, Patti, Francesco, Buccafusca, Maria |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology Amyotrophic lateral sclerosis Histocompatibility antigens Human leukocyte antigen Multiple sclerosis 2708 Neurology (clinical) Psychiatry and Mental Health Neurology Central nervous system Amyotrophic lateral sclerosis Histocompatibility antigens Human leukocyte antigen Multiple sclerosis Dermatology 03 medical and health sciences 0302 clinical medicine Antigen HLA Antigens medicine Humans business.industry General Medicine Middle Aged medicine.disease Histocompatibility Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Immunology Female Neurosurgery business 030217 neurology & neurosurgery |
| Zdroj: | Neurological Sciences. 38:1501-1503 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are two different central nervous system pathology that, according to the most accredited hypotheses, recognize a different etiopathogenesis. The simultaneous occurrence of MS and ALS is quite unusual. To our knowledge, only three cases have been so far described by clinical, laboratory, and post-mortem studies. We report four new cases of this peculiar combination that have been observed and are herein described, included their human leukocyte antigen (HLA) profile studies. On the basis that three out of four patients in our case series presented HLA-B*18:01A, we may hypothesize that this antigen could play a role in developing both diseases. |
| Databáze: | OpenAIRE |
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