Cytokine gene polymorphisms in northern Indian women with recurrent miscarriages
| Autor: | Farah Parveen, Suraksha Agarwal, Anju Shukla |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Genetic Markers Abortion Habitual Adolescent medicine.medical_treatment India Polymorphism Single Nucleotide Young Adult Pregnancy Risk Factors Genotype medicine Prevalence Humans Genetic Predisposition to Disease Allele frequency Retrospective Studies business.industry Case-control study Obstetrics and Gynecology Interleukin medicine.disease Interleukin-10 Cytokine Reproductive Medicine Case-Control Studies Immunology Gestation Cytokines Female Gene polymorphism business |
| Zdroj: | Fertility and sterility. 99(2) |
| ISSN: | 1556-5653 |
| Popis: | Objective To determine association of cytokine gene polymorphism with risk for recurrent miscarriages (RM). Design Retrospective case-control study on northern Indian RM cases versus control subjects. Setting Medical facility. Patient(s) A total of 200 women with at least three unexplained spontaneous abortions before 20 weeks of gestation. Intervention(s) Subjects were genotyped by polymerase chain reaction amplification followed by restriction digestion and allele-specific oligonucleotides. Main Outcome Measure(s) Detection of pro- and antiinflammatory gene polymorphism genotypes and allele frequencies. Result(s) We applied dominant and recessive models of inheritance, showing no association among T H 2 [interleukin (IL) 10 (592 C/A) and transforming growth factor β] gene polymorphisms, while significant association was observed between T H 2 [IL-4 (C590T), IL-6 (G174C), IL-10 (1082A/G and 819C/T)], and T H 1 [interferon-γ (+874A/T)] with RM compared with control subjects. However, when classification and regression tree analysis was applied, this effect disappeared and demonstrated that IL-10 plays an important role in maintenance of pregnancy. Conclusion(s) Interleukin-10 acts as an immunosuppressive by keeping a balance of pro- and antiinflammatory signals that coordinate the satisfactory development of pregnancy, placental growth, and remodeling for favorable pregnancy outcome. |
| Databáze: | OpenAIRE |
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