Antiviral activity and synthesis of quaternized promazine derivatives against HSV-1
| Autor: | Ashley Roe, Shao-Chung Hsia, Akasha K. Purohit, Jacob J. Leichty, Lori M. Ward, Matthew Balish, Miguel O. Mitchell |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
viruses
Clinical Biochemistry Pharmaceutical Science Acyclovir HSL and HSV Herpesvirus 1 Human Virus Replication Biochemistry Antiviral Agents Green fluorescent protein Structure-Activity Relationship Phenothiazines Drug Discovery Chlorocebus aethiops medicine Structure–activity relationship Animals Humans Molecular Biology Vero Cells Treatment timing Promazine Chemistry Organic Chemistry Virology Quaternary Ammonium Compounds Viral replication Vero cell Molecular Medicine Antitubercular Agent medicine.drug |
| Zdroj: | Bioorganicmedicinal chemistry letters. 22(16) |
| ISSN: | 1464-3405 |
| Popis: | N-(4-chlorobenzyl)triflupromazinium chloride, a known antitubercular agent, has been found to also be active against HSV-1. A preliminary structure-activity relation has been explored to determine which groups are crucial to viral inhibition. Antiviral assessments such as GFP reduction, plaque reduction, treatment timing and wash-out studies have also been probed to determine a mode of action for QPD-1. Based on this preliminary data, it appears that QPD-1 is a reversible inhibitor, suspected to inhibit early stages of viral replication of HSV-1 at 50 μM, equipotent to acyclovir. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect