The Urinary Angiotensinogen to Urinary Albumin Ratio Reflects Whether the Renin-angiotensin System in the Kidney Is Activated due to Filtration of Plasma Angiotensinogen through the Damaged Glomeruli or the Production of Angiotensinogen in the Proximal Tubules

Autor: Takashi Matsuyama, Taichi Sato, Shinsuke Isobe, Akihiko Kato, Naoko Katahashi, Tomoyuki Fujikura, Hideo Yasuda, Taro Aoki, Sayaka Ishigaki, Naro Ohashi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Urinary albumin
Urinary system
Kidney Glomerulus
Angiotensinogen
030204 cardiovascular system & hematology
urologic and male genital diseases
Nephropathy
Kidney Tubules
Proximal
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Membranous nephropathy
Internal medicine
Renin–angiotensin system
parasitic diseases
Internal Medicine
Medicine
Albuminuria
Humans
Renal Insufficiency
Chronic
Aged
Kidney
business.industry
Albumin
General Medicine
Middle Aged
medicine.disease
equipment and supplies
urinary angiotensinogen to urinary albumin ratio
intrarenal renin-angiotensin system
medicine.anatomical_structure
Endocrinology
030211 gastroenterology & hepatology
Multiple linear regression analysis
Original Article
Female
business
chronic kidney disease
Zdroj: Internal Medicine
ISSN: 1349-7235
0918-2918
Popis: Objective Urinary angiotensinogen (AGT) is a surrogate marker for intrarenal renin-angiotensin system (RAS) activity that plays an important role in the development of renal damage. Urinary AGT levels are determined by the filtration of plasma AGT through the damaged glomeruli and production of AGT in the proximal tubules. However, the relative merits of the filtration and production of urinary AGT levels in chronic kidney diseases (CKD) have not been clarified. Therefore, we investigated them in CKD patients. Methods We recruited 41 biopsy-proven patients diagnosed with IgA nephropathy (IgAN) in 31, membranous nephropathy (MN) in 5, and tubulointerstitial nephritis (TIN) in 5. The patients taking RAS blockers were excluded. Results The urinary albumin levels in MN patients were significantly higher and those in TIN patients significantly lower than in IgAN patients, and the urinary AGT levels in the MN and TIN patients were significantly higher than those in IgAN patients. Conversely, the urinary AGT-to-urinary albumin (urinary AGT/Alb) ratios were the same for IgAN and MN patients, and those of TIN patients were significantly higher than those of IgAN and MN patients. A multiple linear regression analysis revealed that the urinary AGT/Alb ratios had a significant positive association with IgAN and TIN after adjustments (β=0.75, and p
Databáze: OpenAIRE
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